Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN)

Ashokkumar A. Patel, Dilipkumar Gupta, David Seligson, Eyas M. Hattab, Ulysses J. Balis, Thomas Ulbright, Isaac S. Kohane, Jules J. Berman, John R. Gilbertson, Sarah Dry, Osvaldo Schirripa, Hong Yu, Michael J. Becich, Anil V. Parwani

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet) and a service component (providing histopathologically annotated tissue specimens for medical research). This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Methods: Four centers evaluated pathology reports (1990-2005) for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Results: Common tumors cases (n = 400), the institutional retrieval rates (all blocks) were 83% (A), 95% (B), 80% (C), and 98% (D). Retrieval rate (tumor blocks) from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84%) and lowest-prostate (54%). Rare tumors cases (n = 400), each institution's retrieval rates (all blocks) were 78% (A), 73% (B), 67% (C), and 84% (D). Retrieval rate (tumor blocks) from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72%) and lowest for adenoid cystic carcinoma (58%). Conclusion: A ssessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.

Original languageEnglish
Article number37
JournalBMC Cancer
Volume7
DOIs
StatePublished - 2007

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Informatics
Paraffin
Pathology
Neoplasms
Adenoid Cystic Carcinoma
Prostate
Adenocarcinoma
Clinical Laboratory Information Systems
Research Personnel
Adrenocortical Carcinoma
Mycosis Fungoides

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Availability and quality of paraffin blocks identified in pathology archives : A multi-institutional study by the Shared Pathology Informatics Network (SPIN). / Patel, Ashokkumar A.; Gupta, Dilipkumar; Seligson, David; Hattab, Eyas M.; Balis, Ulysses J.; Ulbright, Thomas; Kohane, Isaac S.; Berman, Jules J.; Gilbertson, John R.; Dry, Sarah; Schirripa, Osvaldo; Yu, Hong; Becich, Michael J.; Parwani, Anil V.

In: BMC Cancer, Vol. 7, 37, 2007.

Research output: Contribution to journalArticle

Patel, AA, Gupta, D, Seligson, D, Hattab, EM, Balis, UJ, Ulbright, T, Kohane, IS, Berman, JJ, Gilbertson, JR, Dry, S, Schirripa, O, Yu, H, Becich, MJ & Parwani, AV 2007, 'Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN)', BMC Cancer, vol. 7, 37. https://doi.org/10.1186/1471-2407-7-37
Patel, Ashokkumar A. ; Gupta, Dilipkumar ; Seligson, David ; Hattab, Eyas M. ; Balis, Ulysses J. ; Ulbright, Thomas ; Kohane, Isaac S. ; Berman, Jules J. ; Gilbertson, John R. ; Dry, Sarah ; Schirripa, Osvaldo ; Yu, Hong ; Becich, Michael J. ; Parwani, Anil V. / Availability and quality of paraffin blocks identified in pathology archives : A multi-institutional study by the Shared Pathology Informatics Network (SPIN). In: BMC Cancer. 2007 ; Vol. 7.
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title = "Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN)",
abstract = "Background: Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet) and a service component (providing histopathologically annotated tissue specimens for medical research). This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Methods: Four centers evaluated pathology reports (1990-2005) for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Results: Common tumors cases (n = 400), the institutional retrieval rates (all blocks) were 83{\%} (A), 95{\%} (B), 80{\%} (C), and 98{\%} (D). Retrieval rate (tumor blocks) from all centers for common tumors was 73{\%} with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84{\%}) and lowest-prostate (54{\%}). Rare tumors cases (n = 400), each institution's retrieval rates (all blocks) were 78{\%} (A), 73{\%} (B), 67{\%} (C), and 84{\%} (D). Retrieval rate (tumor blocks) from all centers for rare tumors was 66{\%} with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72{\%}) and lowest for adenoid cystic carcinoma (58{\%}). Conclusion: A ssessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.",
author = "Patel, {Ashokkumar A.} and Dilipkumar Gupta and David Seligson and Hattab, {Eyas M.} and Balis, {Ulysses J.} and Thomas Ulbright and Kohane, {Isaac S.} and Berman, {Jules J.} and Gilbertson, {John R.} and Sarah Dry and Osvaldo Schirripa and Hong Yu and Becich, {Michael J.} and Parwani, {Anil V.}",
year = "2007",
doi = "10.1186/1471-2407-7-37",
language = "English",
volume = "7",
journal = "BMC Cancer",
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T1 - Availability and quality of paraffin blocks identified in pathology archives

T2 - A multi-institutional study by the Shared Pathology Informatics Network (SPIN)

AU - Patel, Ashokkumar A.

AU - Gupta, Dilipkumar

AU - Seligson, David

AU - Hattab, Eyas M.

AU - Balis, Ulysses J.

AU - Ulbright, Thomas

AU - Kohane, Isaac S.

AU - Berman, Jules J.

AU - Gilbertson, John R.

AU - Dry, Sarah

AU - Schirripa, Osvaldo

AU - Yu, Hong

AU - Becich, Michael J.

AU - Parwani, Anil V.

PY - 2007

Y1 - 2007

N2 - Background: Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet) and a service component (providing histopathologically annotated tissue specimens for medical research). This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Methods: Four centers evaluated pathology reports (1990-2005) for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Results: Common tumors cases (n = 400), the institutional retrieval rates (all blocks) were 83% (A), 95% (B), 80% (C), and 98% (D). Retrieval rate (tumor blocks) from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84%) and lowest-prostate (54%). Rare tumors cases (n = 400), each institution's retrieval rates (all blocks) were 78% (A), 73% (B), 67% (C), and 84% (D). Retrieval rate (tumor blocks) from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72%) and lowest for adenoid cystic carcinoma (58%). Conclusion: A ssessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.

AB - Background: Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet) and a service component (providing histopathologically annotated tissue specimens for medical research). This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Methods: Four centers evaluated pathology reports (1990-2005) for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Results: Common tumors cases (n = 400), the institutional retrieval rates (all blocks) were 83% (A), 95% (B), 80% (C), and 98% (D). Retrieval rate (tumor blocks) from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84%) and lowest-prostate (54%). Rare tumors cases (n = 400), each institution's retrieval rates (all blocks) were 78% (A), 73% (B), 67% (C), and 84% (D). Retrieval rate (tumor blocks) from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72%) and lowest for adenoid cystic carcinoma (58%). Conclusion: A ssessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.

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