Axial mechanical properties of fresh human cerebral blood vessels

Kenneth L. Monson, Werner Goldsmith, Nicholas Barbaro, Geoffrey T. Manley

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Human cerebral blood vessels are frequently damaged in head impact, whether accidental or deliberate, resulting in intracranial bleeding. Additionally, the vasculature constitutes the support structure for the brain and, hence, plays a key role in the cranial load response. Quantification of its mechanical behavior, including limiting loads, is thus required for a proper understanding and modeling of traumatic brain injury - as well as providing substantial assistance in the development and application of preventive measures. It is believed that axial stretching is the dominant loading mode for the blood vessels, regardless of the nature of the insult. Eighteen arteries and fourteen veins were obtained from the cortical surface of the cerebral temporal lobe of patients undergoing surgery. These vessels were stretched to failure in the longitudinal direction, either quasistatically or dynamically. The significance of specimen and experiment parameters was determined using multivariate analysis of variance (MANOVA) testing. Results demonstrate that the arteries were considerably stiffer than the veins, carrying approximately twice as much stress at failure but withstanding only half as much stretch. No significant rate dependence was measured over a strain rate range of more than four orders of magnitude (0.01 to 500 s-1).

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalJournal of Biomechanical Engineering
Volume125
Issue number2
DOIs
StatePublished - Apr 2003
Externally publishedYes

Fingerprint

Blood vessels
Blood Vessels
Veins
Brain
Arteries
Mechanical properties
Temporal Lobe
Analysis of variance (ANOVA)
Surgery
Stretching
Strain rate
Analysis of Variance
Multivariate Analysis
Head
Hemorrhage
Testing
Experiments
Traumatic Brain Injury
Direction compound

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

Axial mechanical properties of fresh human cerebral blood vessels. / Monson, Kenneth L.; Goldsmith, Werner; Barbaro, Nicholas; Manley, Geoffrey T.

In: Journal of Biomechanical Engineering, Vol. 125, No. 2, 04.2003, p. 288-294.

Research output: Contribution to journalArticle

Monson, KL, Goldsmith, W, Barbaro, N & Manley, GT 2003, 'Axial mechanical properties of fresh human cerebral blood vessels', Journal of Biomechanical Engineering, vol. 125, no. 2, pp. 288-294. https://doi.org/10.1115/1.1554412
Monson, Kenneth L. ; Goldsmith, Werner ; Barbaro, Nicholas ; Manley, Geoffrey T. / Axial mechanical properties of fresh human cerebral blood vessels. In: Journal of Biomechanical Engineering. 2003 ; Vol. 125, No. 2. pp. 288-294.
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