Axon and ganglion cell injury in rabbits after percutaneous trigeminal balloon compression

Jeffrey A. Brown, Brian Hoeflinger, Phillip B. Long, William T. Gunning, Robert Rhoades, Carol A. Bennett-Clarke, Nicholas L. Chiaia, Michael T. Weaver

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

NEW ZEALAND WHITE rabbits were used to determine whether the changes in the Vth cranial nerve sensory root after compression were associated with the loss of a specific subclass of Vth cranial nerve ganglion cells, the disappearance of a distinct subset of primary afferent terminals in Vth cranial nerve nucleus caudalis, and/or injury to a specific axonal fiber type. There was no significant difference in the size of surviving ganglion cells after Vth cranial nerve compression, as measured 2 to 3 months after injury (P > 0.5, n = 4). Densitometric analysis of the nerves of rabbits that survived >2 months after compression showed no significant difference in the immunoreactivity of substance P and calcitonin gene-reactive protein between compressed and control sides (P > 0.1, n = 4). Fink-Heimer staining of the Vth cranial nerve subnucleus caudalis revealed that transganglionic degeneration was most dense in the deeper layers, which are the sites of termination of large myelinated fibers. Ultrastructural evaluation of the type of myelinated axons injured by Vth cranial nerve compression in rabbits killed 7, 14, 37, and 270 days after injury was studied, and morphometric analysis was performed. The frequency distribution of axon diameters was significantly different for injured and control areas. The injured areas had higher ratios of small (

Original languageEnglish (US)
Pages (from-to)993-1004
Number of pages12
JournalNeurosurgery
Volume38
Issue number5
DOIs
StatePublished - May 1996
Externally publishedYes

Fingerprint

Cranial Nerves
Ganglia
Axons
Rabbits
Wounds and Injuries
Calcitonin
Substance P
Staining and Labeling
Neurons
Proteins

Keywords

  • Facial pain
  • Trigeminal nerve
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Brown, J. A., Hoeflinger, B., Long, P. B., Gunning, W. T., Rhoades, R., Bennett-Clarke, C. A., ... Weaver, M. T. (1996). Axon and ganglion cell injury in rabbits after percutaneous trigeminal balloon compression. Neurosurgery, 38(5), 993-1004. https://doi.org/10.1097/00006123-199605000-00028

Axon and ganglion cell injury in rabbits after percutaneous trigeminal balloon compression. / Brown, Jeffrey A.; Hoeflinger, Brian; Long, Phillip B.; Gunning, William T.; Rhoades, Robert; Bennett-Clarke, Carol A.; Chiaia, Nicholas L.; Weaver, Michael T.

In: Neurosurgery, Vol. 38, No. 5, 05.1996, p. 993-1004.

Research output: Contribution to journalArticle

Brown, JA, Hoeflinger, B, Long, PB, Gunning, WT, Rhoades, R, Bennett-Clarke, CA, Chiaia, NL & Weaver, MT 1996, 'Axon and ganglion cell injury in rabbits after percutaneous trigeminal balloon compression', Neurosurgery, vol. 38, no. 5, pp. 993-1004. https://doi.org/10.1097/00006123-199605000-00028
Brown JA, Hoeflinger B, Long PB, Gunning WT, Rhoades R, Bennett-Clarke CA et al. Axon and ganglion cell injury in rabbits after percutaneous trigeminal balloon compression. Neurosurgery. 1996 May;38(5):993-1004. https://doi.org/10.1097/00006123-199605000-00028
Brown, Jeffrey A. ; Hoeflinger, Brian ; Long, Phillip B. ; Gunning, William T. ; Rhoades, Robert ; Bennett-Clarke, Carol A. ; Chiaia, Nicholas L. ; Weaver, Michael T. / Axon and ganglion cell injury in rabbits after percutaneous trigeminal balloon compression. In: Neurosurgery. 1996 ; Vol. 38, No. 5. pp. 993-1004.
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