Axotomy-Induced Changes in Ribosomal RNA Levels in Female Hamster Facial Motoneurons: Differential Effects of Gender and Androgen Exposure

Nancy B. Kinderman, Kathryn Jones

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Following facial nerve injury, female hamster facial motoneurons (HFMN) regenerate faster than their male counterparts. Testosterone propionate (TP) markedly accelerates the rate of facial nerve regeneration in males, but has a relatively reduced effect in females. In the present study, we utilized in situ hybridization in conjunction with ribosomal DNA probes to test the hypothesis that in females HFMN axotomy produces a less dramatic cell body response than in males and to examine gender differences in the effects of steroids on peripheral nerve regeneration at the molecular level. The results indicate that in females axotomy alone induced moderate increases in rRNA levels, beginning 2 days postoperatively. These changes were both slower in onset and lower in magnitude than those in the males. TP augmented the effects of axotomy on rRNA levels at the later postoperative times. There were no early, rapid effects of TP, like those observed in males. These molecular data substantiate our previous findings of inherent sex differences in neuronal regeneration and the ability of gonadal steroids to augment the reparative response of peripheral neurons to injury.

Original languageEnglish (US)
Pages (from-to)144-148
Number of pages5
JournalExperimental Neurology
Volume126
Issue number1
DOIs
StatePublished - Mar 1994
Externally publishedYes

Fingerprint

Axotomy
Ribosomal RNA
Motor Neurons
Cricetinae
Androgens
Testosterone Propionate
Nerve Regeneration
Facial Nerve Injuries
Steroids
DNA Probes
Facial Nerve
Ribosomal DNA
Peripheral Nerves
Sex Characteristics
In Situ Hybridization
Regeneration
Neurons
Wounds and Injuries

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Axotomy-Induced Changes in Ribosomal RNA Levels in Female Hamster Facial Motoneurons : Differential Effects of Gender and Androgen Exposure. / Kinderman, Nancy B.; Jones, Kathryn.

In: Experimental Neurology, Vol. 126, No. 1, 03.1994, p. 144-148.

Research output: Contribution to journalArticle

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