Azidoacridines as photoaffinity probes for ionic channels in excitable membranes

Gerry S. Oxford, Richard A. Hudson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Quinacrine and a photoactivatable congener, quinacrine azide, were applied to the intracellular membrane surface of voltage-clamped squid giant axons using internal perfusion techniques. Both compounds were found to reversibly block voltage-dependent sodium channels under dark conditions. Potassium channels were blocked to a lesser extent. Upon irradiation an irreversible block of sodium channels developed with quinacrine azide, but not with quinacrine. Quinacrine azide may thus represent a class of useful photoaffinity probes of voltage-dependent ionic channels.

Original languageEnglish (US)
Pages (from-to)1579-1584
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume104
Issue number4
DOIs
StatePublished - Feb 26 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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