Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation

Michael B. Kays, Matthew F. Wack, David W. Smith, Gerald Denys

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In this report, we describe an azithromycin treatment failure in community-acquired pneumonia. During the first three days of azithromycin, the patient's symptoms worsened, and she was subsequently admitted to the hospital. Blood cultures were positive for a penicillin-susceptible, macrolide-resistant S. pneumoniae. DNA sequencing revealed an A2059G mutation in domain V of the 23S rRNA. To our knowledge, this is the first clinical report of an azithromycin failure in the treatment of S. pneumoniae resistant to macrolides by this mechanism.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume43
Issue number2
DOIs
StatePublished - Jul 2 2002

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Azithromycin
Macrolides
Streptococcus pneumoniae
Treatment Failure
Pneumonia
Mutation
DNA Sequence Analysis
Penicillins

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Virology
  • Parasitology
  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology

Cite this

Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation. / Kays, Michael B.; Wack, Matthew F.; Smith, David W.; Denys, Gerald.

In: Diagnostic Microbiology and Infectious Disease, Vol. 43, No. 2, 02.07.2002, p. 163-165.

Research output: Contribution to journalArticle

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