Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation

Michael B. Kays, Matthew F. Wack, David W. Smith, Gerald A. Denys

Research output: Contribution to journalArticle

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In this report, we describe an azithromycin treatment failure in community-acquired pneumonia. During the first three days of azithromycin, the patient's symptoms worsened, and she was subsequently admitted to the hospital. Blood cultures were positive for a penicillin-susceptible, macrolide-resistant S. pneumoniae. DNA sequencing revealed an A2059G mutation in domain V of the 23S rRNA. To our knowledge, this is the first clinical report of an azithromycin failure in the treatment of S. pneumoniae resistant to macrolides by this mechanism.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Issue number2
StatePublished - Jul 2 2002


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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