B-Type Natriuretic Peptide-Guided Therapy and Length of Hospital Stay Post Left Ventricular Assist Device Implantation

Yaron Hellman, Adnan S. Malik, Hongbo Lin, Changyu Shen, I. Wen Wang, Thomas C. Wozniak, Zubair A. Hashmi, Arslan Shaukat, Jeanette Pickrell, Marco A. Caccamo, Irmina Gradus-Pizlo, Azam Hadi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


B-type natriuretic peptide (BNP)-guided therapy during the early postoperative period following left ventricular assist device (LVAD) implantation has not been well described in the literature. We conducted a retrospective cohort study consisting of consecutive patients who underwent LVAD implantation at our institution during May 2009 to March 2013. The study was limited to patients receiving HeartMate II (Thoratec) or HVAD (HeartWare) LVADs. Patients with acute myocardial infarction were excluded. We compared between patients with multiple postoperative BNP tests (BNP-guided therapy) and earlier period patients who typically had only a baseline BNP measurement (non-BNP-guided therapy). A total of 85 patients underwent LVAD implantation during the study period. Eight patients were excluded (five acute myocardial infarction, three without BNP measurements). The only differences in the baseline characteristics of BNP versus non-BNP-guided therapy included age and female gender. The postoperative length of hospital stay (LOS) in the BNP-guided therapy group was 5 days shorter when compared with the non-BNP-guided therapy group. In multivariate analysis, BNP-guided therapy remained a significant predictor of reduced LOS. The use of repeated BNP measurements during the early postoperative period was associated with a significantly lower LOS post LVAD implantation.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalASAIO Journal
Issue number2
StatePublished - Jul 21 2015


  • B-type natriuretic peptide
  • BNP-guided therapy
  • left ventricular assist device
  • length of hospital stay

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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