Bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia

Sean Amsbaugh, Erin Huiras, Nadia S. Wang, Aaron Wever, Simon Warren

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Bacillary angiomatosis is an opportunistic bacterial infection caused by either Bartonella henselae or B. quintana. The classic histologic presentation of bacillary angiomatosis involves three components: a lobular proliferation of capillaries with enlarged endothelial cells, neutrophilic debris, and clumps of finely granular material identified as bacteria with staining techniques. Pseudoepitheliomatous hyperplasia is a histologic reaction pattern characterized by epithelial proliferation in response to a variety of stimuli, including mycobacterial, fungal, and bacterial infections. We describe a case of bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia in an immunocompromised patient with Acquired Immunodeficiency Syndrome. Histologic examination of a finger lesion demonstrated a capillary proliferation with neutrophilic debris and characteristic amorphous granular deposits. Warthin-Starry and Giemsa staining revealed clumps of coccobacilli. Cervical lymph node tissue also revealed organisms identified as Bartonella with PCR techniques. Stains and cultures for acid fast bacilli, fungus, and bacteria were negative. To our knowledge, there has been only one other report of bacillary angiomatosis presenting with pseudoepitheliomatous hyperplasia. We conclude that the differential diagnosis of entities associated with pseudoepitheliomatous hyperplasia should be expanded to include bacillary angiomatosis.

Original languageEnglish (US)
Pages (from-to)32-35
Number of pages4
JournalAmerican Journal of Dermatopathology
Volume28
Issue number1
DOIs
StatePublished - Feb 2006
Externally publishedYes

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Bacillary Angiomatosis
Hyperplasia
Bacterial Infections
Bartonella henselae
Bartonella
Staining and Labeling
Bacteria
Mycoses
Opportunistic Infections
Immunocompromised Host
Bacillus
Fingers
Acquired Immunodeficiency Syndrome
Differential Diagnosis
Fungi
Coloring Agents
Endothelial Cells
Lymph Nodes
Polymerase Chain Reaction
Acids

Keywords

  • Bacillary angiomatosis
  • Bartonella
  • Pseudoepitheliomatous hyperplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

Bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia. / Amsbaugh, Sean; Huiras, Erin; Wang, Nadia S.; Wever, Aaron; Warren, Simon.

In: American Journal of Dermatopathology, Vol. 28, No. 1, 02.2006, p. 32-35.

Research output: Contribution to journalArticle

Amsbaugh, Sean ; Huiras, Erin ; Wang, Nadia S. ; Wever, Aaron ; Warren, Simon. / Bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia. In: American Journal of Dermatopathology. 2006 ; Vol. 28, No. 1. pp. 32-35.
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