Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins

A. Dunker, Christopher J. Oldfield

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

From the 1970s to the present, regions of missing electron density in protein structures determined by X-ray diffraction and the characterization of the functions of these regions have suggested that not all protein regions depend on prior 3D structure to carry out function. Motivated by these observations, in early 1996 we began to use bioinformatics approaches to study these intrinsically disordered proteins (IDPs) and IDP regions. At just about the same time, several laboratory groups began to study a collection of IDPs and IDP regions using nuclear magnetic resonance. The temporal overlap of the bioinformatics and NMR studies played a significant role in the development of our understanding of IDPs. Here the goal is to recount some of this history and to project from this experience possible directions for future work.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-34
Number of pages34
Volume870
DOIs
StatePublished - Sep 22 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume870
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Intrinsically Disordered Proteins
Bioinformatics
Computational Biology
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
X-Ray Diffraction
Carrier concentration
Proteins
History
Electrons
X ray diffraction

Keywords

  • Protein structure and function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Dunker, A., & Oldfield, C. J. (2015). Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. In Advances in Experimental Medicine and Biology (Vol. 870, pp. 1-34). (Advances in Experimental Medicine and Biology; Vol. 870). Springer New York LLC. https://doi.org/10.1007/978-3-319-20164-1_1

Back to the future : Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. / Dunker, A.; Oldfield, Christopher J.

Advances in Experimental Medicine and Biology. Vol. 870 Springer New York LLC, 2015. p. 1-34 (Advances in Experimental Medicine and Biology; Vol. 870).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dunker, A & Oldfield, CJ 2015, Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. in Advances in Experimental Medicine and Biology. vol. 870, Advances in Experimental Medicine and Biology, vol. 870, Springer New York LLC, pp. 1-34. https://doi.org/10.1007/978-3-319-20164-1_1
Dunker A, Oldfield CJ. Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. In Advances in Experimental Medicine and Biology. Vol. 870. Springer New York LLC. 2015. p. 1-34. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-20164-1_1
Dunker, A. ; Oldfield, Christopher J. / Back to the future : Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. Advances in Experimental Medicine and Biology. Vol. 870 Springer New York LLC, 2015. pp. 1-34 (Advances in Experimental Medicine and Biology).
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