Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins

A. Keith Dunker, Christopher J. Oldfield

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

From the 1970s to the present, regions of missing electron density in protein structures determined by X-ray diffraction and the characterization of the functions of these regions have suggested that not all protein regions depend on prior 3D structure to carry out function. Motivated by these observations, in early 1996 we began to use bioinformatics approaches to study these intrinsically disordered proteins (IDPs) and IDP regions. At just about the same time, several laboratory groups began to study a collection of IDPs and IDP regions using nuclear magnetic resonance. The temporal overlap of the bioinformatics and NMR studies played a significant role in the development of our understanding of IDPs. Here the goal is to recount some of this history and to project from this experience possible directions for future work.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-34
Number of pages34
DOIs
StatePublished - Sep 22 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume870
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Protein structure and function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Dunker, A. K., & Oldfield, C. J. (2015). Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. In Advances in Experimental Medicine and Biology (pp. 1-34). (Advances in Experimental Medicine and Biology; Vol. 870). Springer New York LLC. https://doi.org/10.1007/978-3-319-20164-1_1