Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins

A. Dunker, Christopher J. Oldfield

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

From the 1970s to the present, regions of missing electron density in protein structures determined by X-ray diffraction and the characterization of the functions of these regions have suggested that not all protein regions depend on prior 3D structure to carry out function. Motivated by these observations, in early 1996 we began to use bioinformatics approaches to study these intrinsically disordered proteins (IDPs) and IDP regions. At just about the same time, several laboratory groups began to study a collection of IDPs and IDP regions using nuclear magnetic resonance. The temporal overlap of the bioinformatics and NMR studies played a significant role in the development of our understanding of IDPs. Here the goal is to recount some of this history and to project from this experience possible directions for future work.

Original languageEnglish (US)
Title of host publicationIntrinsically Disordered Proteins Studied by NMR Spectroscopy
PublisherSpringer International Publishing
Pages1-34
Number of pages34
ISBN (Print)9783319201641, 9783319201634
DOIs
StatePublished - Sep 19 2015

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Intrinsically Disordered Proteins
Bioinformatics
Computational Biology
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
X-Ray Diffraction
Carrier concentration
Proteins
History
Electrons
X ray diffraction

Keywords

  • Protein structure and function

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dunker, A., & Oldfield, C. J. (2015). Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. In Intrinsically Disordered Proteins Studied by NMR Spectroscopy (pp. 1-34). Springer International Publishing. https://doi.org/10.1007/978-3-319-20164-1_1

Back to the future : Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. / Dunker, A.; Oldfield, Christopher J.

Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing, 2015. p. 1-34.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dunker, A & Oldfield, CJ 2015, Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. in Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing, pp. 1-34. https://doi.org/10.1007/978-3-319-20164-1_1
Dunker A, Oldfield CJ. Back to the future: Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. In Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing. 2015. p. 1-34 https://doi.org/10.1007/978-3-319-20164-1_1
Dunker, A. ; Oldfield, Christopher J. / Back to the future : Nuclear magnetic resonance and bioinformatics studies on intrinsically disordered proteins. Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing, 2015. pp. 1-34
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