Back to your heart: Ubiquitin proteasome system-regulated signal transduction

Andrea L. Portbury, Sarah M. Ronnebaum, Makhosazane Zungu, Cam Patterson, Monte S. Willis

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Awareness of the regulation of cell signaling by post-translational ubiquitination has emerged over the past 2 decades. Like phosphorylation, post-translational modification of proteins with ubiquitin can result in the regulation of numerous cellular functions, for example, the DNA damage response, apoptosis, cell growth, and the innate immune response. In this review, we discuss recently published mechanisms by which the ubiquitin proteasome system regulates key signal transduction pathways in the heart, including MAPK JNK, calcineurin, FOXO, p53, and estrogen receptors α and β. We then explore how ubiquitin proteasome system-specific regulation of these signal transduction pathways plays a role in the pathophysiology of common cardiac diseases, such as cardiac hypertrophy, heart failure, ischemia reperfusion injury, and diabetes. This article is part of a Special Section entitled "Post-translational Modification.".

Original languageEnglish (US)
Pages (from-to)526-537
Number of pages12
JournalJournal of Molecular and Cellular Cardiology
Volume52
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Keywords

  • C-Jun
  • Calcineurin
  • Cardiac hypertrophy
  • Diabetes
  • Estrogen receptor
  • FOXO
  • Ischemia
  • JNK
  • P53
  • Proteasome
  • Ubiquitin

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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