Bacterial resistance to β-lactam antibiotics: Compelling opportunism, compelling opportunity

Jed F. Fisher, Samy O. Meroueh, Shahriar Mobashery

Research output: Contribution to journalReview article

670 Scopus citations


Bacteria thrive under extreme conditions and they can adjust easily so as to improve their fitness for survival. This review covers bacterial tolerance and resistance to the β-lactam antibiotics. It describes penicillin-binding proteins and β-lactamases. Under penicillin-binding proteins, enzymes of cell wall biosynthesis and β-lactam-sensing proteins are introduced. Under β-lactamases, the four classes of β-lactamases are described.

Original languageEnglish (US)
Pages (from-to)395-424
Number of pages30
JournalChemical Reviews
Issue number2
StatePublished - Feb 1 2005


ASJC Scopus subject areas

  • Chemistry(all)

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