Bak Expression and Cell Death Occur in Peritumorous Tissue but not in Pancreatic Cancer Cells

Hans U. Graber, Helmut Friess, Arthur Zimmermann, Murray Korc, Guido Adler, Roland Schmid, Markus W. Büchler

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Bak is a pro-apoptotic member of the Bcl-2 family whose genes are involved in regulation of programmed cell death. Using in situ hybridization, immunohistochemistry, and Northern blot analysis, we studied the expression of Bak in specimens from 12 normal pancreata and 26 primary pancreatic cancers, and correlated the findings with the clinical and histopathologic data of the patients. By comparison with normal pancreas, Northern blot analysis demonstrated a 2.5-fold increase of Bak messenger RNA expression in the tumor samples (P

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume3
Issue number1
StatePublished - Jan 1999
Externally publishedYes

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Pancreatic Neoplasms
Northern Blotting
Pancreas
Cell Death
In Situ Hybridization
Immunohistochemistry
Messenger RNA
Genes
Neoplasms

Keywords

  • Apoptosis
  • Bak expression
  • Carcinogenesis
  • In situ hybridization
  • Pancreatic cancer

ASJC Scopus subject areas

  • Surgery

Cite this

Graber, H. U., Friess, H., Zimmermann, A., Korc, M., Adler, G., Schmid, R., & Büchler, M. W. (1999). Bak Expression and Cell Death Occur in Peritumorous Tissue but not in Pancreatic Cancer Cells. Journal of Gastrointestinal Surgery, 3(1), 74-81.

Bak Expression and Cell Death Occur in Peritumorous Tissue but not in Pancreatic Cancer Cells. / Graber, Hans U.; Friess, Helmut; Zimmermann, Arthur; Korc, Murray; Adler, Guido; Schmid, Roland; Büchler, Markus W.

In: Journal of Gastrointestinal Surgery, Vol. 3, No. 1, 01.1999, p. 74-81.

Research output: Contribution to journalArticle

Graber, HU, Friess, H, Zimmermann, A, Korc, M, Adler, G, Schmid, R & Büchler, MW 1999, 'Bak Expression and Cell Death Occur in Peritumorous Tissue but not in Pancreatic Cancer Cells', Journal of Gastrointestinal Surgery, vol. 3, no. 1, pp. 74-81.
Graber HU, Friess H, Zimmermann A, Korc M, Adler G, Schmid R et al. Bak Expression and Cell Death Occur in Peritumorous Tissue but not in Pancreatic Cancer Cells. Journal of Gastrointestinal Surgery. 1999 Jan;3(1):74-81.
Graber, Hans U. ; Friess, Helmut ; Zimmermann, Arthur ; Korc, Murray ; Adler, Guido ; Schmid, Roland ; Büchler, Markus W. / Bak Expression and Cell Death Occur in Peritumorous Tissue but not in Pancreatic Cancer Cells. In: Journal of Gastrointestinal Surgery. 1999 ; Vol. 3, No. 1. pp. 74-81.
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