Bariatric surgery as a renoprotective intervention

Allon Friedman, Ricardo V. Cohen

Research output: Contribution to journalReview article

Abstract

Purpose of review Through its direct adverse effects on the kidney and via associated intermediate disease states like type 2 diabetes and hypertension, obese has arguably become the master risk factor for chronic kidney disease (CKD). The purpose of this review is to critically evaluate bariatric surgery, which is the most effective weight reduction strategy available, as a renoprotective strategy. Recent findings Recent randomized studies confirm that bariatric surgery is effective at improving or even remitting major CKD risk factors such as type 2 diabetes and hypertension. In addition, observational studies performed primarily in patients without preexisting CKD report improvements in estimated glomerular filtration rate and albuminuria after bariatric surgery. Yet this literature is limited by study design, participant selection, statistical power, and measurement issues that must be overcome to better define kidney-related benefits, especially with regard to harder kidney-related and other clinical endpoints. Summary Encouraging data exist on the renoprotective effects of bariatric surgery. However, important knowledge gaps still remain. Future research should focus on studying, ideally in randomized fashion, the renoprotective effects of bariatric surgery in patients with preexisting CKD to better define the benefit-risk ratio for each patient.

Original languageEnglish (US)
JournalCurrent Opinion in Nephrology and Hypertension
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Bariatric Surgery
Chronic Renal Insufficiency
Kidney
Type 2 Diabetes Mellitus
Hypertension
Albuminuria
Glomerular Filtration Rate
Observational Studies
Weight Loss
Odds Ratio

Keywords

  • albuminuria
  • bariatric surgery
  • chronic kidney disease
  • estimated glomerular filtration rate
  • obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

Cite this

Bariatric surgery as a renoprotective intervention. / Friedman, Allon; Cohen, Ricardo V.

In: Current Opinion in Nephrology and Hypertension, 01.01.2019.

Research output: Contribution to journalReview article

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