Basal-like and triple-negative breast cancers

A critical review with an emphasis on the implications for pathologists and oncologists

Sunil Badve, David J. Dabbs, Stuart J. Schnitt, Frederick L. Baehner, Thomas Decker, Vincenzo Eusebi, Stephen B. Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R. Lakhani, José Palacios, Emad A. Rakha, Andrea L. Richardson, Fernando C. Schmitt, Puay Hoon Tan, Gary M. Tse, Britta Weigelt, Ian O. Ellis, Jorge S. Reis-Filho

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for basal-like cancer, which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists.

Original languageEnglish
Pages (from-to)157-167
Number of pages11
JournalModern Pathology
Volume24
Issue number2
DOIs
StatePublished - Feb 2011

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Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasms
Gene Expression
Oncologists
Pathologists

Keywords

  • basal-like
  • breast cancer
  • definition
  • practical review
  • triple-negative

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Basal-like and triple-negative breast cancers : A critical review with an emphasis on the implications for pathologists and oncologists. / Badve, Sunil; Dabbs, David J.; Schnitt, Stuart J.; Baehner, Frederick L.; Decker, Thomas; Eusebi, Vincenzo; Fox, Stephen B.; Ichihara, Shu; Jacquemier, Jocelyne; Lakhani, Sunil R.; Palacios, José; Rakha, Emad A.; Richardson, Andrea L.; Schmitt, Fernando C.; Tan, Puay Hoon; Tse, Gary M.; Weigelt, Britta; Ellis, Ian O.; Reis-Filho, Jorge S.

In: Modern Pathology, Vol. 24, No. 2, 02.2011, p. 157-167.

Research output: Contribution to journalArticle

Badve, S, Dabbs, DJ, Schnitt, SJ, Baehner, FL, Decker, T, Eusebi, V, Fox, SB, Ichihara, S, Jacquemier, J, Lakhani, SR, Palacios, J, Rakha, EA, Richardson, AL, Schmitt, FC, Tan, PH, Tse, GM, Weigelt, B, Ellis, IO & Reis-Filho, JS 2011, 'Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists', Modern Pathology, vol. 24, no. 2, pp. 157-167. https://doi.org/10.1038/modpathol.2010.200
Badve, Sunil ; Dabbs, David J. ; Schnitt, Stuart J. ; Baehner, Frederick L. ; Decker, Thomas ; Eusebi, Vincenzo ; Fox, Stephen B. ; Ichihara, Shu ; Jacquemier, Jocelyne ; Lakhani, Sunil R. ; Palacios, José ; Rakha, Emad A. ; Richardson, Andrea L. ; Schmitt, Fernando C. ; Tan, Puay Hoon ; Tse, Gary M. ; Weigelt, Britta ; Ellis, Ian O. ; Reis-Filho, Jorge S. / Basal-like and triple-negative breast cancers : A critical review with an emphasis on the implications for pathologists and oncologists. In: Modern Pathology. 2011 ; Vol. 24, No. 2. pp. 157-167.
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