Baseline body mass index among children and adults undergoing allogeneic hematopoietic cell transplantation

Clinical characteristics and outcomes

M. Gleimer, Y. Li, L. Chang, Sophie Paczesny, D. A. Hanauer, D. G. Frame, C. A. Byersdorfer, P. R. Reddy, T. M. Braun, S. W. Choi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Obesity is an important public health problem that may influence the outcomes of hematopoietic cell transplantation (HCT). We studied 898 children and adults receiving first-time allogeneic hematopoietic SCTs between 2004 and 2012. Pretransplant body mass index (BMI) was classified as underweight, normal weight, overweight or obese using the WHO classification or age-adjusted BMI percentiles for children. The study population was predominantly Caucasian, and the median age was 51 years (5 months-73 years). The cumulative 3-year incidence of nonrelapse mortality (NRM) in underweight, normal weight, overweight and obese patients was 20%, 19%, 20% and 33%, respectively. Major causes of NRM were acute and chronic GVHD. The corresponding incidence of relapse was 30%, 41%, 37% and 30%, respectively. Three-year OS was 59%, 48%, 47% and 43%, respectively. Multivariate analysis showed that obesity was associated with higher NRM (hazard ratio (HR) 1.43, P = 0.04) and lower relapse (HR 0.65, P = 0.002). Pretransplant plasma levels of ST2 and TNFR1 biomarkers were significantly higher in obese compared with normal weight patients (P = 0.04 and P = 0.05, respectively). The increase in NRM observed in obese patients was partially offset by a lower incidence of relapse with no difference in OS.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalBone Marrow Transplantation
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2015

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Cell Transplantation
Body Mass Index
Mortality
Thinness
Weights and Measures
Recurrence
Incidence
Obesity
Receptors, Tumor Necrosis Factor, Type I
Multivariate Analysis
Public Health
Biomarkers
Population

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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Baseline body mass index among children and adults undergoing allogeneic hematopoietic cell transplantation : Clinical characteristics and outcomes. / Gleimer, M.; Li, Y.; Chang, L.; Paczesny, Sophie; Hanauer, D. A.; Frame, D. G.; Byersdorfer, C. A.; Reddy, P. R.; Braun, T. M.; Choi, S. W.

In: Bone Marrow Transplantation, Vol. 50, No. 3, 01.03.2015, p. 402-410.

Research output: Contribution to journalArticle

Gleimer, M. ; Li, Y. ; Chang, L. ; Paczesny, Sophie ; Hanauer, D. A. ; Frame, D. G. ; Byersdorfer, C. A. ; Reddy, P. R. ; Braun, T. M. ; Choi, S. W. / Baseline body mass index among children and adults undergoing allogeneic hematopoietic cell transplantation : Clinical characteristics and outcomes. In: Bone Marrow Transplantation. 2015 ; Vol. 50, No. 3. pp. 402-410.
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