Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years

Nicholas A. Moore, Alon Harris, Scott Wentz, Alice Chandra Verticchio Vercellin, Priyanka Parekh, Joshua Gross, Rehan M. Hussain, Claudia Thieme, Brent Siesky

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/aims Previous studies suggest that vascular abnormalities are involved in the pathogenesis of open-angle glaucoma. This study aims to examine the relationship of baseline retrobulbar blood flow measurements with functional and structural glaucomatous progression in patients with open-angle glaucoma over 4 years. Methods In this study, 112 patients with open-angle glaucoma were examined at baseline and 78 with retrobulbar blood flow assessments were followed to 4 years. Colour Doppler imaging was used to evaluate retrobulbar blood flow. Structural disease progression was examined with optical coherence tomography and Heidelberg Retinal Tomography III. Functional disease progression was monitored with automated perimetry using Humphrey visual fields. Mixed-model analysis of covariance was used to test for significance of changes from baseline to 4-year follow-up. Two-sample t tests and ?2 tests were used to test for baseline blood flow differences between patients who progressed and those who did not progress. Results Patients who progressed structurally had a statistically significant lower baseline mean ophthalmic artery peak systolic velocity (PSV) (p=0.024) and ophthalmic artery end diastolic velocity (EDV) (p=0.012) compared with those who did not progress. Similarly, a lower baseline mean ophthalmic artery PSV ( p=0.031) and ophthalmic artery EDV ( p=0.005) were associated with patients who progressed functionally compared with those who did not progress after 4 years. Conclusions In this study population, lower baseline ophthalmic artery blood flow velocities were associated with simultaneous structural and functional glaucoma progression after 4 years.

Original languageEnglish (US)
JournalBritish Journal of Ophthalmology
DOIs
StateAccepted/In press - Jun 13 2016

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Ophthalmic Artery
Open Angle Glaucoma
Disease Progression
Visual Field Tests
Blood Flow Velocity
Optical Coherence Tomography
Hematologic Tests
Visual Fields
Glaucoma
Blood Vessels
Color
Tomography
Population

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years. / Moore, Nicholas A.; Harris, Alon; Wentz, Scott; Vercellin, Alice Chandra Verticchio; Parekh, Priyanka; Gross, Joshua; Hussain, Rehan M.; Thieme, Claudia; Siesky, Brent.

In: British Journal of Ophthalmology, 13.06.2016.

Research output: Contribution to journalArticle

Moore, Nicholas A. ; Harris, Alon ; Wentz, Scott ; Vercellin, Alice Chandra Verticchio ; Parekh, Priyanka ; Gross, Joshua ; Hussain, Rehan M. ; Thieme, Claudia ; Siesky, Brent. / Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years. In: British Journal of Ophthalmology. 2016.
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N2 - Background/aims Previous studies suggest that vascular abnormalities are involved in the pathogenesis of open-angle glaucoma. This study aims to examine the relationship of baseline retrobulbar blood flow measurements with functional and structural glaucomatous progression in patients with open-angle glaucoma over 4 years. Methods In this study, 112 patients with open-angle glaucoma were examined at baseline and 78 with retrobulbar blood flow assessments were followed to 4 years. Colour Doppler imaging was used to evaluate retrobulbar blood flow. Structural disease progression was examined with optical coherence tomography and Heidelberg Retinal Tomography III. Functional disease progression was monitored with automated perimetry using Humphrey visual fields. Mixed-model analysis of covariance was used to test for significance of changes from baseline to 4-year follow-up. Two-sample t tests and ?2 tests were used to test for baseline blood flow differences between patients who progressed and those who did not progress. Results Patients who progressed structurally had a statistically significant lower baseline mean ophthalmic artery peak systolic velocity (PSV) (p=0.024) and ophthalmic artery end diastolic velocity (EDV) (p=0.012) compared with those who did not progress. Similarly, a lower baseline mean ophthalmic artery PSV ( p=0.031) and ophthalmic artery EDV ( p=0.005) were associated with patients who progressed functionally compared with those who did not progress after 4 years. Conclusions In this study population, lower baseline ophthalmic artery blood flow velocities were associated with simultaneous structural and functional glaucoma progression after 4 years.

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