Basic fibroblast growth factor is a calcium-mobilizing secretagogue in rat pancreatic acini

Bysani Chandrasekar, Murray Korc

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Basic fibroblast growth factor (bFGF) induced a marked increase in the levels of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and a rapid rise in cytosolic free calcium [Ca2+]i levels in rat pancreatic acini. The bFGF-mediated calcium transient was not dependent on the presence of extracellular calcium, and was abolished by pretreatment of acini with carbachol. bFGF stimulated amylase release in pancreatic acini in a monophasic, dose-dependent manner, and this effect was blocked by neutralizing anti-bFGF antibodies. At much higher concentrations, epidermal growth factor (EGF), but not insulin-like growth factor-I (IGF-I), partially mimicked some of the actions of bFGF. These findings suggest that bFGF is a previously unrecognized calcium-mobilizing pancreatic secretagogue that may participate in the regulation of pancreatic exocrine function.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume177
Issue number1
DOIs
StatePublished - May 31 1991
Externally publishedYes

Fingerprint

Fibroblast Growth Factor 2
Rats
Calcium
Inositol 1,4,5-Trisphosphate
Carbachol
Amylases
Insulin-Like Growth Factor I
Epidermal Growth Factor
Antibodies

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Basic fibroblast growth factor is a calcium-mobilizing secretagogue in rat pancreatic acini. / Chandrasekar, Bysani; Korc, Murray.

In: Biochemical and Biophysical Research Communications, Vol. 177, No. 1, 31.05.1991, p. 166-170.

Research output: Contribution to journalArticle

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