Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

Theresa Guise, Khalid Mohammad, Gregory Clines, Elizabeth G. Stebbins, Darren H. Wong, Linda S. Higgins, Robert Vessella, Eva Corey, Susan Padalecki, Larry Suva, John Chirgwin, Pearse, Roodman, Lipton, Clohisy, Weilbaecher, Smith

Research output: Contribution to journalArticle

326 Citations (Scopus)

Abstract

Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

Original languageEnglish (US)
JournalClinical Cancer Research
Volume12
Issue number20 PART 2
DOIs
StatePublished - Oct 15 2006
Externally publishedYes

Fingerprint

Neoplasm Metastasis
Bone and Bones
Bone Development
Neoplasms
Osteogenesis
Osteolysis
Osteoclasts
Osteoblasts
Steroids
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. / Guise, Theresa; Mohammad, Khalid; Clines, Gregory; Stebbins, Elizabeth G.; Wong, Darren H.; Higgins, Linda S.; Vessella, Robert; Corey, Eva; Padalecki, Susan; Suva, Larry; Chirgwin, John; Pearse; Roodman; Lipton; Clohisy; Weilbaecher; Smith.

In: Clinical Cancer Research, Vol. 12, No. 20 PART 2, 15.10.2006.

Research output: Contribution to journalArticle

Guise, T, Mohammad, K, Clines, G, Stebbins, EG, Wong, DH, Higgins, LS, Vessella, R, Corey, E, Padalecki, S, Suva, L, Chirgwin, J, Pearse, Roodman, Lipton, Clohisy, Weilbaecher & Smith 2006, 'Basic mechanisms responsible for osteolytic and osteoblastic bone metastases', Clinical Cancer Research, vol. 12, no. 20 PART 2. https://doi.org/10.1158/1078-0432.CCR-06-1007
Guise, Theresa ; Mohammad, Khalid ; Clines, Gregory ; Stebbins, Elizabeth G. ; Wong, Darren H. ; Higgins, Linda S. ; Vessella, Robert ; Corey, Eva ; Padalecki, Susan ; Suva, Larry ; Chirgwin, John ; Pearse ; Roodman ; Lipton ; Clohisy ; Weilbaecher ; Smith. / Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. In: Clinical Cancer Research. 2006 ; Vol. 12, No. 20 PART 2.
@article{2501613448374521ae1432d19df6192d,
title = "Basic mechanisms responsible for osteolytic and osteoblastic bone metastases",
abstract = "Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.",
author = "Theresa Guise and Khalid Mohammad and Gregory Clines and Stebbins, {Elizabeth G.} and Wong, {Darren H.} and Higgins, {Linda S.} and Robert Vessella and Eva Corey and Susan Padalecki and Larry Suva and John Chirgwin and Pearse and Roodman and Lipton and Clohisy and Weilbaecher and Smith",
year = "2006",
month = "10",
day = "15",
doi = "10.1158/1078-0432.CCR-06-1007",
language = "English (US)",
volume = "12",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "20 PART 2",

}

TY - JOUR

T1 - Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

AU - Guise, Theresa

AU - Mohammad, Khalid

AU - Clines, Gregory

AU - Stebbins, Elizabeth G.

AU - Wong, Darren H.

AU - Higgins, Linda S.

AU - Vessella, Robert

AU - Corey, Eva

AU - Padalecki, Susan

AU - Suva, Larry

AU - Chirgwin, John

AU - Pearse,

AU - Roodman,

AU - Lipton,

AU - Clohisy,

AU - Weilbaecher,

AU - Smith,

PY - 2006/10/15

Y1 - 2006/10/15

N2 - Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

AB - Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

UR - http://www.scopus.com/inward/record.url?scp=33750738067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750738067&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-06-1007

DO - 10.1158/1078-0432.CCR-06-1007

M3 - Article

C2 - 17062703

AN - SCOPUS:33750738067

VL - 12

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 20 PART 2

ER -