bcl-2 expression in normal adrenal glands and in adrenal neoplasms

Franz Fogt, Alexander Vortmeyer, C. Poremba, M. Minda, C. A. Harris, J. E. Tomaszewski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Archival paraffin-embedded tissue from 5 normal adrenal glands (including 1 from a fetus of 28 weeks' gestation), 6 cases of adrenal cortical hyperplasia, 9 cortical adenomas, 14 cortical carcinomas, and 11 pheochromocytomas were immunostained with monoclonal antibody against bcl-2. Ultrastructural localization of bcl-2 protein was also performed on selected cases. Positive immunostaining for bcl-2 was seen in all of the layers of the normal adrenal cortex, with different staining characteristics. bcl-2 expression was never observed in the normal adrenal medulla. Electron microscopic studies revealed bcl-2 to be localized predominantly to mitochondria, with a small number of labels along the nuclear envelope. Analysis of adrenal neoplasms showed expression of bcl-2 in cortical tumors, but only one positive case in pheochromocytomas. Restriction of bcl-2 expression to adrenal cortex-derived tissue versus adrenal medulla-derived tissue might prove to be helpful for the differential diagnosis between cortical and medullary tumors.

Original languageEnglish (US)
Pages (from-to)716-720
Number of pages5
JournalModern Pathology
Volume11
Issue number8
StatePublished - Aug 1 1998
Externally publishedYes

Fingerprint

Adrenal Gland Neoplasms
Adrenal Glands
Adrenal Medulla
Adrenal Cortex
Pheochromocytoma
Brain Stem Neoplasms
Nuclear Envelope
Adenoma
Paraffin
Hyperplasia
Mitochondria
Fetus
Differential Diagnosis
Monoclonal Antibodies
Electrons
Staining and Labeling
Carcinoma
Pregnancy
Neoplasms
Proteins

Keywords

  • Adrenal gland
  • Apoptosis
  • Bcl-2
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Fogt, F., Vortmeyer, A., Poremba, C., Minda, M., Harris, C. A., & Tomaszewski, J. E. (1998). bcl-2 expression in normal adrenal glands and in adrenal neoplasms. Modern Pathology, 11(8), 716-720.

bcl-2 expression in normal adrenal glands and in adrenal neoplasms. / Fogt, Franz; Vortmeyer, Alexander; Poremba, C.; Minda, M.; Harris, C. A.; Tomaszewski, J. E.

In: Modern Pathology, Vol. 11, No. 8, 01.08.1998, p. 716-720.

Research output: Contribution to journalArticle

Fogt, F, Vortmeyer, A, Poremba, C, Minda, M, Harris, CA & Tomaszewski, JE 1998, 'bcl-2 expression in normal adrenal glands and in adrenal neoplasms', Modern Pathology, vol. 11, no. 8, pp. 716-720.
Fogt F, Vortmeyer A, Poremba C, Minda M, Harris CA, Tomaszewski JE. bcl-2 expression in normal adrenal glands and in adrenal neoplasms. Modern Pathology. 1998 Aug 1;11(8):716-720.
Fogt, Franz ; Vortmeyer, Alexander ; Poremba, C. ; Minda, M. ; Harris, C. A. ; Tomaszewski, J. E. / bcl-2 expression in normal adrenal glands and in adrenal neoplasms. In: Modern Pathology. 1998 ; Vol. 11, No. 8. pp. 716-720.
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