BCL-6 regulates chemokine gene transcription in macrophages

Lisa M. Toney, Giorgio Cattoretti, Jennifer A. Graf, Taha Merghoub, Pier Paolo Pandolfi, Riccardo Dalla-Favera, B. Hilda Ye, Alexander Dent

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalNature Immunology
Volume1
Issue number3
StatePublished - Sep 2000

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Chemokines
Macrophages
Inflammation
Genes
Repressor Proteins
T-Lymphocyte Subsets
B-Cell Lymphoma
Innate Immunity
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Toney, L. M., Cattoretti, G., Graf, J. A., Merghoub, T., Pandolfi, P. P., Dalla-Favera, R., ... Dent, A. (2000). BCL-6 regulates chemokine gene transcription in macrophages. Nature Immunology, 1(3), 214-220.

BCL-6 regulates chemokine gene transcription in macrophages. / Toney, Lisa M.; Cattoretti, Giorgio; Graf, Jennifer A.; Merghoub, Taha; Pandolfi, Pier Paolo; Dalla-Favera, Riccardo; Ye, B. Hilda; Dent, Alexander.

In: Nature Immunology, Vol. 1, No. 3, 09.2000, p. 214-220.

Research output: Contribution to journalArticle

Toney, LM, Cattoretti, G, Graf, JA, Merghoub, T, Pandolfi, PP, Dalla-Favera, R, Ye, BH & Dent, A 2000, 'BCL-6 regulates chemokine gene transcription in macrophages', Nature Immunology, vol. 1, no. 3, pp. 214-220.
Toney LM, Cattoretti G, Graf JA, Merghoub T, Pandolfi PP, Dalla-Favera R et al. BCL-6 regulates chemokine gene transcription in macrophages. Nature Immunology. 2000 Sep;1(3):214-220.
Toney, Lisa M. ; Cattoretti, Giorgio ; Graf, Jennifer A. ; Merghoub, Taha ; Pandolfi, Pier Paolo ; Dalla-Favera, Riccardo ; Ye, B. Hilda ; Dent, Alexander. / BCL-6 regulates chemokine gene transcription in macrophages. In: Nature Immunology. 2000 ; Vol. 1, No. 3. pp. 214-220.
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