BCL-6 regulates chemokine gene transcription in macrophages

Lisa M. Toney, Giorgio Cattoretti, Jennifer A. Graf, Taha Merghoub, Pier Paolo Pandolfi, Riccardo Dalla-Favera, B. Hilda Ye, Alexander L. Dent

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalNature Immunology
Volume1
Issue number3
DOIs
StatePublished - Sep 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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