A strong association between the Philadelphia chromosome (Ph1) and chronic myelogenous leukemia (CML) suggests that the Ph1 translocation plays a significant role in pathogenesis of CML. For this reason, Ph1-positive leukemias have been well studied from the molecular, clinical and cell biological perspective. In this review article, intracellular signalling events involving BCR/ABL fusion gene products are discussed in the context of the role of the Ph1 chromosome in human leukemia.
|Original language||English (US)|
|Number of pages||8|
|Journal||International Journal of Hematology|
|State||Published - Apr 1 1995|
- Chronic myelogenous leukemia
ASJC Scopus subject areas