BCR/ABL signal transduction

Tetsuzo Tauchi, Hal E. Broxmeyer

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

A strong association between the Philadelphia chromosome (Ph1) and chronic myelogenous leukemia (CML) suggests that the Ph1 translocation plays a significant role in pathogenesis of CML. For this reason, Ph1-positive leukemias have been well studied from the molecular, clinical and cell biological perspective. In this review article, intracellular signalling events involving BCR/ABL fusion gene products are discussed in the context of the role of the Ph1 chromosome in human leukemia.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalInternational Journal of Hematology
Volume61
Issue number3
StatePublished - Apr 1 1995

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Keywords

  • BCR/ABL
  • Chronic myelogenous leukemia
  • Ph

ASJC Scopus subject areas

  • Hematology

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