Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

Brandon G. Oberlin, Mario Dzemidzic, Stella M. Tran, Christina M. Soeurt, Sean O'Connor, Karmen Yoder, David Kareken

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Rationale: Although striatal dopamine (DA) is important in alcohol abuse, the nature of DA release during actual alcohol drinking is unclear, since drinking includes self-administration of both conditioned flavor stimuli (CS) of the alcoholic beverage and subsequent intoxication, the unconditioned stimulus (US). Objectives: Here, we used a novel self-administration analog to distinguish nucleus accumbens (NAcc) DA responses specific to the CS and US. Methods: Right-handed male heavy drinkers (n∈=∈26) received three positron emission tomography (PET) scans with the D2/D3 radioligand [11C]raclopride (RAC) and performed a pseudo self-administration task that separately administered a flavor CS of either a habitually consumed beer or the appetitive control Gatorade®, concomitant with the US of ethanol intoxication (0.06 g/dL intravenous (IV) administration) or IV saline. Scan conditions were Gatorade flavor∈+∈saline (Gat&Sal), Gatorade flavor∈+∈ethanol (Gat&Eth), and beer flavor∈+∈ethanol (Beer&Eth). Results: Ethanol (US) reduced RAC binding (inferring DA release) in the left (L) NAcc [Gat&Sal∈>∈Gat&Eth]. Beer flavor (CS) increased DA in the right (R) NAcc [Gat&Eth∈>∈Beer&Eth]. The combination of beer flavor and ethanol (CS∈+∈US), [Gat&Sal∈>∈Beer&Eth], induced DA release in bilateral NAcc. Self-reported intoxication during scanning correlated with L NAcc DA release. Relative to saline, infusion of ethanol increased alcoholic drink wanting. Conclusions: Our findings suggest lateralized DA function in the NAcc, with L NAcc DA release most reflecting intoxication, R NAcc DA release most reflecting the flavor CS, and the conjoint CS∈+∈US producing a bilateral NAcc response.

Original languageEnglish
Pages (from-to)861-870
Number of pages10
JournalPsychopharmacology
Volume232
Issue number5
DOIs
StatePublished - 2015

Fingerprint

Self Administration
Nucleus Accumbens
Dopamine
Ethanol
Raclopride
Corpus Striatum
Alcoholic Beverages
Alcohol Drinking
Intravenous Administration
Positron-Emission Tomography
Alcoholism
Drinking
gatorade

Keywords

  • Alcohol abuse
  • Alcohol seeking
  • Alcoholism
  • Conditioned response
  • Cue reactivity
  • Instrumental conditioning
  • Mesolimbic
  • Operant
  • Reward
  • Ventral striatum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers. / Oberlin, Brandon G.; Dzemidzic, Mario; Tran, Stella M.; Soeurt, Christina M.; O'Connor, Sean; Yoder, Karmen; Kareken, David.

In: Psychopharmacology, Vol. 232, No. 5, 2015, p. 861-870.

Research output: Contribution to journalArticle

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abstract = "Rationale: Although striatal dopamine (DA) is important in alcohol abuse, the nature of DA release during actual alcohol drinking is unclear, since drinking includes self-administration of both conditioned flavor stimuli (CS) of the alcoholic beverage and subsequent intoxication, the unconditioned stimulus (US). Objectives: Here, we used a novel self-administration analog to distinguish nucleus accumbens (NAcc) DA responses specific to the CS and US. Methods: Right-handed male heavy drinkers (n∈=∈26) received three positron emission tomography (PET) scans with the D2/D3 radioligand [11C]raclopride (RAC) and performed a pseudo self-administration task that separately administered a flavor CS of either a habitually consumed beer or the appetitive control Gatorade{\circledR}, concomitant with the US of ethanol intoxication (0.06 g/dL intravenous (IV) administration) or IV saline. Scan conditions were Gatorade flavor∈+∈saline (Gat&Sal), Gatorade flavor∈+∈ethanol (Gat&Eth), and beer flavor∈+∈ethanol (Beer&Eth). Results: Ethanol (US) reduced RAC binding (inferring DA release) in the left (L) NAcc [Gat&Sal∈>∈Gat&Eth]. Beer flavor (CS) increased DA in the right (R) NAcc [Gat&Eth∈>∈Beer&Eth]. The combination of beer flavor and ethanol (CS∈+∈US), [Gat&Sal∈>∈Beer&Eth], induced DA release in bilateral NAcc. Self-reported intoxication during scanning correlated with L NAcc DA release. Relative to saline, infusion of ethanol increased alcoholic drink wanting. Conclusions: Our findings suggest lateralized DA function in the NAcc, with L NAcc DA release most reflecting intoxication, R NAcc DA release most reflecting the flavor CS, and the conjoint CS∈+∈US producing a bilateral NAcc response.",
keywords = "Alcohol abuse, Alcohol seeking, Alcoholism, Conditioned response, Cue reactivity, Instrumental conditioning, Mesolimbic, Operant, Reward, Ventral striatum",
author = "Oberlin, {Brandon G.} and Mario Dzemidzic and Tran, {Stella M.} and Soeurt, {Christina M.} and Sean O'Connor and Karmen Yoder and David Kareken",
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T1 - Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

AU - Oberlin, Brandon G.

AU - Dzemidzic, Mario

AU - Tran, Stella M.

AU - Soeurt, Christina M.

AU - O'Connor, Sean

AU - Yoder, Karmen

AU - Kareken, David

PY - 2015

Y1 - 2015

N2 - Rationale: Although striatal dopamine (DA) is important in alcohol abuse, the nature of DA release during actual alcohol drinking is unclear, since drinking includes self-administration of both conditioned flavor stimuli (CS) of the alcoholic beverage and subsequent intoxication, the unconditioned stimulus (US). Objectives: Here, we used a novel self-administration analog to distinguish nucleus accumbens (NAcc) DA responses specific to the CS and US. Methods: Right-handed male heavy drinkers (n∈=∈26) received three positron emission tomography (PET) scans with the D2/D3 radioligand [11C]raclopride (RAC) and performed a pseudo self-administration task that separately administered a flavor CS of either a habitually consumed beer or the appetitive control Gatorade®, concomitant with the US of ethanol intoxication (0.06 g/dL intravenous (IV) administration) or IV saline. Scan conditions were Gatorade flavor∈+∈saline (Gat&Sal), Gatorade flavor∈+∈ethanol (Gat&Eth), and beer flavor∈+∈ethanol (Beer&Eth). Results: Ethanol (US) reduced RAC binding (inferring DA release) in the left (L) NAcc [Gat&Sal∈>∈Gat&Eth]. Beer flavor (CS) increased DA in the right (R) NAcc [Gat&Eth∈>∈Beer&Eth]. The combination of beer flavor and ethanol (CS∈+∈US), [Gat&Sal∈>∈Beer&Eth], induced DA release in bilateral NAcc. Self-reported intoxication during scanning correlated with L NAcc DA release. Relative to saline, infusion of ethanol increased alcoholic drink wanting. Conclusions: Our findings suggest lateralized DA function in the NAcc, with L NAcc DA release most reflecting intoxication, R NAcc DA release most reflecting the flavor CS, and the conjoint CS∈+∈US producing a bilateral NAcc response.

AB - Rationale: Although striatal dopamine (DA) is important in alcohol abuse, the nature of DA release during actual alcohol drinking is unclear, since drinking includes self-administration of both conditioned flavor stimuli (CS) of the alcoholic beverage and subsequent intoxication, the unconditioned stimulus (US). Objectives: Here, we used a novel self-administration analog to distinguish nucleus accumbens (NAcc) DA responses specific to the CS and US. Methods: Right-handed male heavy drinkers (n∈=∈26) received three positron emission tomography (PET) scans with the D2/D3 radioligand [11C]raclopride (RAC) and performed a pseudo self-administration task that separately administered a flavor CS of either a habitually consumed beer or the appetitive control Gatorade®, concomitant with the US of ethanol intoxication (0.06 g/dL intravenous (IV) administration) or IV saline. Scan conditions were Gatorade flavor∈+∈saline (Gat&Sal), Gatorade flavor∈+∈ethanol (Gat&Eth), and beer flavor∈+∈ethanol (Beer&Eth). Results: Ethanol (US) reduced RAC binding (inferring DA release) in the left (L) NAcc [Gat&Sal∈>∈Gat&Eth]. Beer flavor (CS) increased DA in the right (R) NAcc [Gat&Eth∈>∈Beer&Eth]. The combination of beer flavor and ethanol (CS∈+∈US), [Gat&Sal∈>∈Beer&Eth], induced DA release in bilateral NAcc. Self-reported intoxication during scanning correlated with L NAcc DA release. Relative to saline, infusion of ethanol increased alcoholic drink wanting. Conclusions: Our findings suggest lateralized DA function in the NAcc, with L NAcc DA release most reflecting intoxication, R NAcc DA release most reflecting the flavor CS, and the conjoint CS∈+∈US producing a bilateral NAcc response.

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KW - Cue reactivity

KW - Instrumental conditioning

KW - Mesolimbic

KW - Operant

KW - Reward

KW - Ventral striatum

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