Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients

John Nurnberger, Elliot S. Gershon, Susan Simmons, Michael Ebert, Linda R. Kessler, Eleanor D. Dibble, Suzanne S. Jimerson, Gregory M. Brown, Philip Gold, David C. Jimerson, Juliet J. Guroff, Fredric I. Storch

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

An i.v. injection of dextroamphetamine (0.3 mgm/kg) was given to 13 pairs of normal monozygotic twins, three pairs of normal dizygotic twins and 11 patients with bipolar affective disorder in remission and off medications. Behavioral excitation in response to amphetamine was highly correlated in monozygotic twins; it was predicted by the baseline variables of high plasma MHPG, low serum prolactin and low pulse; it correlated with a rise in cortisol; and it was not correlated with plasma amphetamine level. Pre-infusion baseline MHPG and growth hormone and prolactin responses to amphetamine also were concordant in twins. Plasma amphetamine level, pulse and blood pressure and cortisol responses were not concordant, suggesting significant environmental influences. Haloperidol pretreatment in one pair of twins abolished the excitation response but did not reduce increases in cortisol and growth hormone. This suggests a role for dopamine in the excitation response but predominant serotonergic and noradrenergic mediation of the hormonal responses. None of the responses or baseline measures distinguished patients from controls. Thus, no consistently altered sensitivity to monoaminergic stimulation by amphetamine in bipolar affective disorder was demonstrated in this study. This is one of the first reports of familial (possibly genetic) variation in a psychostimulant drug response in man. The responses identified as concordant may be useful in characterizing other pathologic conditions.

Original languageEnglish (US)
Pages (from-to)163-176
Number of pages14
JournalPsychoneuroendocrinology
Volume7
Issue number2-3
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Amphetamine
Methoxyhydroxyphenylglycol
Hydrocortisone
Monozygotic Twins
Mood Disorders
Bipolar Disorder
Prolactin
Growth Hormone
Blood Pressure
Dizygotic Twins
Dextroamphetamine
Haloperidol
Dopamine
Injections
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients. / Nurnberger, John; Gershon, Elliot S.; Simmons, Susan; Ebert, Michael; Kessler, Linda R.; Dibble, Eleanor D.; Jimerson, Suzanne S.; Brown, Gregory M.; Gold, Philip; Jimerson, David C.; Guroff, Juliet J.; Storch, Fredric I.

In: Psychoneuroendocrinology, Vol. 7, No. 2-3, 1982, p. 163-176.

Research output: Contribution to journalArticle

Nurnberger, J, Gershon, ES, Simmons, S, Ebert, M, Kessler, LR, Dibble, ED, Jimerson, SS, Brown, GM, Gold, P, Jimerson, DC, Guroff, JJ & Storch, FI 1982, 'Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients', Psychoneuroendocrinology, vol. 7, no. 2-3, pp. 163-176. https://doi.org/10.1016/0306-4530(82)90009-9
Nurnberger, John ; Gershon, Elliot S. ; Simmons, Susan ; Ebert, Michael ; Kessler, Linda R. ; Dibble, Eleanor D. ; Jimerson, Suzanne S. ; Brown, Gregory M. ; Gold, Philip ; Jimerson, David C. ; Guroff, Juliet J. ; Storch, Fredric I. / Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients. In: Psychoneuroendocrinology. 1982 ; Vol. 7, No. 2-3. pp. 163-176.
@article{a49f964893cb42da91ab78ca0d458070,
title = "Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients",
abstract = "An i.v. injection of dextroamphetamine (0.3 mgm/kg) was given to 13 pairs of normal monozygotic twins, three pairs of normal dizygotic twins and 11 patients with bipolar affective disorder in remission and off medications. Behavioral excitation in response to amphetamine was highly correlated in monozygotic twins; it was predicted by the baseline variables of high plasma MHPG, low serum prolactin and low pulse; it correlated with a rise in cortisol; and it was not correlated with plasma amphetamine level. Pre-infusion baseline MHPG and growth hormone and prolactin responses to amphetamine also were concordant in twins. Plasma amphetamine level, pulse and blood pressure and cortisol responses were not concordant, suggesting significant environmental influences. Haloperidol pretreatment in one pair of twins abolished the excitation response but did not reduce increases in cortisol and growth hormone. This suggests a role for dopamine in the excitation response but predominant serotonergic and noradrenergic mediation of the hormonal responses. None of the responses or baseline measures distinguished patients from controls. Thus, no consistently altered sensitivity to monoaminergic stimulation by amphetamine in bipolar affective disorder was demonstrated in this study. This is one of the first reports of familial (possibly genetic) variation in a psychostimulant drug response in man. The responses identified as concordant may be useful in characterizing other pathologic conditions.",
author = "John Nurnberger and Gershon, {Elliot S.} and Susan Simmons and Michael Ebert and Kessler, {Linda R.} and Dibble, {Eleanor D.} and Jimerson, {Suzanne S.} and Brown, {Gregory M.} and Philip Gold and Jimerson, {David C.} and Guroff, {Juliet J.} and Storch, {Fredric I.}",
year = "1982",
doi = "10.1016/0306-4530(82)90009-9",
language = "English (US)",
volume = "7",
pages = "163--176",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Elsevier Limited",
number = "2-3",

}

TY - JOUR

T1 - Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients

AU - Nurnberger, John

AU - Gershon, Elliot S.

AU - Simmons, Susan

AU - Ebert, Michael

AU - Kessler, Linda R.

AU - Dibble, Eleanor D.

AU - Jimerson, Suzanne S.

AU - Brown, Gregory M.

AU - Gold, Philip

AU - Jimerson, David C.

AU - Guroff, Juliet J.

AU - Storch, Fredric I.

PY - 1982

Y1 - 1982

N2 - An i.v. injection of dextroamphetamine (0.3 mgm/kg) was given to 13 pairs of normal monozygotic twins, three pairs of normal dizygotic twins and 11 patients with bipolar affective disorder in remission and off medications. Behavioral excitation in response to amphetamine was highly correlated in monozygotic twins; it was predicted by the baseline variables of high plasma MHPG, low serum prolactin and low pulse; it correlated with a rise in cortisol; and it was not correlated with plasma amphetamine level. Pre-infusion baseline MHPG and growth hormone and prolactin responses to amphetamine also were concordant in twins. Plasma amphetamine level, pulse and blood pressure and cortisol responses were not concordant, suggesting significant environmental influences. Haloperidol pretreatment in one pair of twins abolished the excitation response but did not reduce increases in cortisol and growth hormone. This suggests a role for dopamine in the excitation response but predominant serotonergic and noradrenergic mediation of the hormonal responses. None of the responses or baseline measures distinguished patients from controls. Thus, no consistently altered sensitivity to monoaminergic stimulation by amphetamine in bipolar affective disorder was demonstrated in this study. This is one of the first reports of familial (possibly genetic) variation in a psychostimulant drug response in man. The responses identified as concordant may be useful in characterizing other pathologic conditions.

AB - An i.v. injection of dextroamphetamine (0.3 mgm/kg) was given to 13 pairs of normal monozygotic twins, three pairs of normal dizygotic twins and 11 patients with bipolar affective disorder in remission and off medications. Behavioral excitation in response to amphetamine was highly correlated in monozygotic twins; it was predicted by the baseline variables of high plasma MHPG, low serum prolactin and low pulse; it correlated with a rise in cortisol; and it was not correlated with plasma amphetamine level. Pre-infusion baseline MHPG and growth hormone and prolactin responses to amphetamine also were concordant in twins. Plasma amphetamine level, pulse and blood pressure and cortisol responses were not concordant, suggesting significant environmental influences. Haloperidol pretreatment in one pair of twins abolished the excitation response but did not reduce increases in cortisol and growth hormone. This suggests a role for dopamine in the excitation response but predominant serotonergic and noradrenergic mediation of the hormonal responses. None of the responses or baseline measures distinguished patients from controls. Thus, no consistently altered sensitivity to monoaminergic stimulation by amphetamine in bipolar affective disorder was demonstrated in this study. This is one of the first reports of familial (possibly genetic) variation in a psychostimulant drug response in man. The responses identified as concordant may be useful in characterizing other pathologic conditions.

UR - http://www.scopus.com/inward/record.url?scp=0019944541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019944541&partnerID=8YFLogxK

U2 - 10.1016/0306-4530(82)90009-9

DO - 10.1016/0306-4530(82)90009-9

M3 - Article

C2 - 6891082

AN - SCOPUS:0019944541

VL - 7

SP - 163

EP - 176

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

IS - 2-3

ER -