Behavioral measures of alcohol self-administration and intake control: Rodent models

Herman H. Samson, Cristine L. Czachowski

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

This review provides a brief historical overview of the behavioral paradigms that have been used to study alcohol consumption using rats as subjects, and then critically evaluates these models' ability to address the complexities involved in ethanol-seeking and self-administration. Many of these models have been influenced by a "behavioral pharmacology" approach, and therefore have studied oral ethanol reinforcement in a manner similar to food and water reinforcement. Because of this, these models have failed to adequately assess the complex seeking responses that are an integral part of ethanol-motivated behaviors. As an alternative, an appetitive-consummatory approach that procedurally separates and measures the two phases of behavior is suggested, and recent data using this model are reviewed. It is important that animal models that are to be used to evaluate underlying physiological mechanisms of the control of ethanol self-administration accurately address all of the complex behaviors that are involved in intake control.

Original languageEnglish (US)
Pages (from-to)107-143
Number of pages37
JournalInternational Review of Neurobiology
Volume54
DOIs
StatePublished - Jan 1 2003

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Rodent Control
Self Administration
Ethanol
Alcohols
Reinforcement
Aptitude
Alcohol Drinking
Animal Models
Pharmacology
Rats
Animals
Food
Rodentia
Water

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Behavioral measures of alcohol self-administration and intake control : Rodent models. / Samson, Herman H.; Czachowski, Cristine L.

In: International Review of Neurobiology, Vol. 54, 01.01.2003, p. 107-143.

Research output: Contribution to journalReview article

Samson, Herman H. ; Czachowski, Cristine L. / Behavioral measures of alcohol self-administration and intake control : Rodent models. In: International Review of Neurobiology. 2003 ; Vol. 54. pp. 107-143.
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