Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury

Joseph T. Giacino, Mark Sherer, Andrea Christoforou, Petra Maurer-Karattup, Flora M. Hammond, David Long, Emilia Bagiella

Research output: Contribution to journalArticle

Abstract

The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction. The aim of this observational cohort study was to systematically track behavioral and functional recovery in patients with prolonged traumatic DoC following discharge from the acute care setting. Standardized behavioral data were acquired from 95 patients in a minimally conscious (MCS) or vegetative state (VS) recruited from 11 clinic sites and randomly assigned to the placebo arm of a previously completed prospective clinical trial. Patients were followed for 6 weeks by blinded observers to determine frequency of recovery of six target behaviors associated with functional status. The Coma Recovery Scale-Revised and Disability Rating Scale were used to track reemergence of target behaviors and assess degree of functional disability, respectively. Twenty percent (95% confidence interval [CI]: 13-30%) of participants (mean age 37.2; median 47 days post-injury; 69 men) recovered all six target behaviors within the 6 week observation period. The odds of recovering a specific target behavior were 3.2 (95% CI: 1.2-8.1) to 7.8 (95% CI: 2.7-23.0) times higher for patients in MCS than for those in VS. Patients with preserved language function ("MCS+") recovered the most behaviors (p ≤ 0.002) and had the least disability (p ≤ 0.002) at follow-up. These findings suggest that recovery of high-level behaviors underpinning functional independence is common in patients with prolonged traumatic DoC. Clinicians involved in early prognostic counseling should recognize that failure to emerge from traumatic DoC before 28 days does not necessarily portend unfavorable outcome.

Original languageEnglish (US)
Pages (from-to)357-365
Number of pages9
JournalJournal of neurotrauma
Volume37
Issue number2
DOIs
StatePublished - Jan 15 2020

Fingerprint

Consciousness
Decision Making
Consciousness Disorders
Persistent Vegetative State
Confidence Intervals
Coma
Traumatic Brain Injury
Observational Studies
Counseling
Cohort Studies
Language
Placebos
Observation
Clinical Trials
Wounds and Injuries

Keywords

  • consciousness
  • MCS
  • outcome research
  • TBI
  • VS

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury. / Giacino, Joseph T.; Sherer, Mark; Christoforou, Andrea; Maurer-Karattup, Petra; Hammond, Flora M.; Long, David; Bagiella, Emilia.

In: Journal of neurotrauma, Vol. 37, No. 2, 15.01.2020, p. 357-365.

Research output: Contribution to journalArticle

Giacino, Joseph T. ; Sherer, Mark ; Christoforou, Andrea ; Maurer-Karattup, Petra ; Hammond, Flora M. ; Long, David ; Bagiella, Emilia. / Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury. In: Journal of neurotrauma. 2020 ; Vol. 37, No. 2. pp. 357-365.
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