Bench to bedside

The role of mitochondrial medicine in the pathogenesis and treatment of cellular injury

John A. Watts, Jeffrey Kline

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Interest in the study of mitochondria has undergone a revival. The term mitochondrial medicine developed around evidence pointing to the mitochondria as a logical target for therapy. This article reviews the normal functions of mitochondria and integration of mitochondrial processes in cells. Changes in mitochondria that occur in ischemia and reperfusion, production of reactive oxygen species by mitochondria, stimulation of apoptosis, and roles of mitochondria in sepsis also are reviewed. The authors also review therapies that are based on targeting drugs to mitochondria, regulating calcium availability, substrate preferences, and activation of poly (ADP-ribose) polymerase and apoptosis. The purpose of this article is to provide a framework for emergency medicine academicians to understand the roles of mitochondria in pathology and to facilitate the transition of this information into therapeutic strategies based on mitochondrial medicine. For individuals interested in the biochemistry of mitochondria, knowledge of this fundamental organelle is expanding at a rapid rate.

Original languageEnglish (US)
Pages (from-to)985-997
Number of pages13
JournalAcademic Emergency Medicine
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

Mitochondria
Medicine
Wounds and Injuries
Therapeutics
Apoptosis
Poly(ADP-ribose) Polymerases
Emergency Medicine
Drug Delivery Systems
Organelles
Biochemistry
Reperfusion
Reactive Oxygen Species
Sepsis
Ischemia
Pathology
Calcium

Keywords

  • Apoptosis
  • Ischemia and reperfusion
  • Mitochondria
  • Reactive oxygen species
  • Sepsis
  • Therapy

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Bench to bedside : The role of mitochondrial medicine in the pathogenesis and treatment of cellular injury. / Watts, John A.; Kline, Jeffrey.

In: Academic Emergency Medicine, Vol. 10, No. 9, 01.09.2003, p. 985-997.

Research output: Contribution to journalArticle

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