Benign metastasizing leiomyoma: Clonality, telomere length and clinicopathologic analysis

Kurt T. Patton, Liang Cheng, Veronica Papavero, Matthew G. Blum, Anjana V. Yeldandi, Brian P. Adley, Chunyan Luan, Leslie K. Diaz, Pei Hui, Ximing J. Yang

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Benign metastasizing leiomyoma is a rare condition affecting women with a history of uterine leiomyomata and is characterized by multiple histologically benign pulmonary smooth muscle tumors. Speculations on its pathogenesis include a benign uterine leiomyoma colonizing the lung, a metastatic low-grade uterine leiomyosarcoma, and primary pulmonary leiomyomatosis. To elucidate its pathogenesis, we analyzed the clinical, pathological and immunohistochemical features, clonality, and telomere length of multiple lung and uterine tumors in three patients with benign metastasizing leiomyoma. In all cases, pulmonary tumors had benign histology and immunohistochemical profiles (estrogen receptor positive, progesterone receptor positive, and very low proliferative index) identical to uterine leiomyoma. In eight tumors from three patients, clonality was assessed by analyzing the variable length of the polymorphic CAG repeat sequence within the human androgen receptor gene. In the two informative patients pulmonary and uterine tumors showed identical patterns of androgen receptor allelic inactivation, indicating that they were clonal. The telomere length measured by fluorescence in situ hybridization in pulmonary leiomyomas of all three patients were either long or very long and were identical to the uterine counterparts, indicating significant telomere shortening is not a crucial step for developing metastases. Our evidence supports the notion that benign metastasizing leiomyoma is clonally derived from benign-appearing uterine leiomyomas.

Original languageEnglish
Pages (from-to)130-140
Number of pages11
JournalModern Pathology
Volume19
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Telomere
Leiomyoma
Lung
Neoplasms
Leiomyomatosis
Smooth Muscle Tumor
Telomere Shortening
Leiomyosarcoma
Androgen Receptors
Progesterone Receptors
Fluorescence In Situ Hybridization
Estrogen Receptors
Histology
Neoplasm Metastasis
Genes

Keywords

  • Clonality
  • Leiomyoma
  • Metastasis
  • Pulmonary
  • Telomere

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Patton, K. T., Cheng, L., Papavero, V., Blum, M. G., Yeldandi, A. V., Adley, B. P., ... Yang, X. J. (2006). Benign metastasizing leiomyoma: Clonality, telomere length and clinicopathologic analysis. Modern Pathology, 19(1), 130-140. https://doi.org/10.1038/modpathol.3800504

Benign metastasizing leiomyoma : Clonality, telomere length and clinicopathologic analysis. / Patton, Kurt T.; Cheng, Liang; Papavero, Veronica; Blum, Matthew G.; Yeldandi, Anjana V.; Adley, Brian P.; Luan, Chunyan; Diaz, Leslie K.; Hui, Pei; Yang, Ximing J.

In: Modern Pathology, Vol. 19, No. 1, 01.2006, p. 130-140.

Research output: Contribution to journalArticle

Patton, KT, Cheng, L, Papavero, V, Blum, MG, Yeldandi, AV, Adley, BP, Luan, C, Diaz, LK, Hui, P & Yang, XJ 2006, 'Benign metastasizing leiomyoma: Clonality, telomere length and clinicopathologic analysis', Modern Pathology, vol. 19, no. 1, pp. 130-140. https://doi.org/10.1038/modpathol.3800504
Patton, Kurt T. ; Cheng, Liang ; Papavero, Veronica ; Blum, Matthew G. ; Yeldandi, Anjana V. ; Adley, Brian P. ; Luan, Chunyan ; Diaz, Leslie K. ; Hui, Pei ; Yang, Ximing J. / Benign metastasizing leiomyoma : Clonality, telomere length and clinicopathologic analysis. In: Modern Pathology. 2006 ; Vol. 19, No. 1. pp. 130-140.
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