Benign vascular tumors, cysts, and pseudocysts of the adrenal gland

a contemporary multi-institutional clinicopathological analysis of 55 cases

Wei Zheng, Kar Ming Fung, Liang Cheng, Adeboye O. Osunkoya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Benign adrenal vascular tumors, cysts, and pseudocysts are a heterogeneous group of relatively uncommon entities that may pose diagnostic challenges radiologically and pathologically. However, there are only a few small cases series systematically characterizing the clinicopathological features of these lesions. We identified 55 cases of benign adrenal vascular tumors, cysts, and pseudocysts (23 pseudocysts, 17 hemangiomas, 8 lymphangiomas, 6 angiomatous endothelial cysts, and 1 arteriovenous malformation) from a multi-institutional urologic pathology database between 2000 and 2017 and retrospectively analyzed their clinicopathological features. We found that these lesions have a female predominance and most are right sided. These lesions may occur simultaneously with other adrenal tumors associated with hormonal hypersecretion. A substantial portion of pseudocysts were semisolid or solid with no fluid collection, mimicking a solid adrenal tumor and resulting in adrenalectomy. In addition, a small proportion of benign vascular lesions may have coexisting epithelial tumors, requiring extensive specimen sampling and thorough microscopic examination.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalHuman Pathology
Volume82
DOIs
StatePublished - Dec 1 2018

Fingerprint

Adrenal Glands
Blood Vessels
Cysts
Glandular and Epithelial Neoplasms
Lymphangioma
Neoplasms
Arteriovenous Malformations
Adrenalectomy
Hemangioma
Databases
Pathology

Keywords

  • Adrenal gland
  • Angiomatous endothelial cyst
  • Hemangioma
  • Lymphangioma
  • Vascular malformation
  • Vascular tumor, cyst, pseudocyst

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Benign vascular tumors, cysts, and pseudocysts of the adrenal gland : a contemporary multi-institutional clinicopathological analysis of 55 cases. / Zheng, Wei; Fung, Kar Ming; Cheng, Liang; Osunkoya, Adeboye O.

In: Human Pathology, Vol. 82, 01.12.2018, p. 95-102.

Research output: Contribution to journalArticle

@article{3b896e53c9e9496b8473018e11f9cf79,
title = "Benign vascular tumors, cysts, and pseudocysts of the adrenal gland: a contemporary multi-institutional clinicopathological analysis of 55 cases",
abstract = "Benign adrenal vascular tumors, cysts, and pseudocysts are a heterogeneous group of relatively uncommon entities that may pose diagnostic challenges radiologically and pathologically. However, there are only a few small cases series systematically characterizing the clinicopathological features of these lesions. We identified 55 cases of benign adrenal vascular tumors, cysts, and pseudocysts (23 pseudocysts, 17 hemangiomas, 8 lymphangiomas, 6 angiomatous endothelial cysts, and 1 arteriovenous malformation) from a multi-institutional urologic pathology database between 2000 and 2017 and retrospectively analyzed their clinicopathological features. We found that these lesions have a female predominance and most are right sided. These lesions may occur simultaneously with other adrenal tumors associated with hormonal hypersecretion. A substantial portion of pseudocysts were semisolid or solid with no fluid collection, mimicking a solid adrenal tumor and resulting in adrenalectomy. In addition, a small proportion of benign vascular lesions may have coexisting epithelial tumors, requiring extensive specimen sampling and thorough microscopic examination.",
keywords = "Adrenal gland, Angiomatous endothelial cyst, Hemangioma, Lymphangioma, Vascular malformation, Vascular tumor, cyst, pseudocyst",
author = "Wei Zheng and Fung, {Kar Ming} and Liang Cheng and Osunkoya, {Adeboye O.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.humpath.2018.07.013",
language = "English (US)",
volume = "82",
pages = "95--102",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Benign vascular tumors, cysts, and pseudocysts of the adrenal gland

T2 - a contemporary multi-institutional clinicopathological analysis of 55 cases

AU - Zheng, Wei

AU - Fung, Kar Ming

AU - Cheng, Liang

AU - Osunkoya, Adeboye O.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Benign adrenal vascular tumors, cysts, and pseudocysts are a heterogeneous group of relatively uncommon entities that may pose diagnostic challenges radiologically and pathologically. However, there are only a few small cases series systematically characterizing the clinicopathological features of these lesions. We identified 55 cases of benign adrenal vascular tumors, cysts, and pseudocysts (23 pseudocysts, 17 hemangiomas, 8 lymphangiomas, 6 angiomatous endothelial cysts, and 1 arteriovenous malformation) from a multi-institutional urologic pathology database between 2000 and 2017 and retrospectively analyzed their clinicopathological features. We found that these lesions have a female predominance and most are right sided. These lesions may occur simultaneously with other adrenal tumors associated with hormonal hypersecretion. A substantial portion of pseudocysts were semisolid or solid with no fluid collection, mimicking a solid adrenal tumor and resulting in adrenalectomy. In addition, a small proportion of benign vascular lesions may have coexisting epithelial tumors, requiring extensive specimen sampling and thorough microscopic examination.

AB - Benign adrenal vascular tumors, cysts, and pseudocysts are a heterogeneous group of relatively uncommon entities that may pose diagnostic challenges radiologically and pathologically. However, there are only a few small cases series systematically characterizing the clinicopathological features of these lesions. We identified 55 cases of benign adrenal vascular tumors, cysts, and pseudocysts (23 pseudocysts, 17 hemangiomas, 8 lymphangiomas, 6 angiomatous endothelial cysts, and 1 arteriovenous malformation) from a multi-institutional urologic pathology database between 2000 and 2017 and retrospectively analyzed their clinicopathological features. We found that these lesions have a female predominance and most are right sided. These lesions may occur simultaneously with other adrenal tumors associated with hormonal hypersecretion. A substantial portion of pseudocysts were semisolid or solid with no fluid collection, mimicking a solid adrenal tumor and resulting in adrenalectomy. In addition, a small proportion of benign vascular lesions may have coexisting epithelial tumors, requiring extensive specimen sampling and thorough microscopic examination.

KW - Adrenal gland

KW - Angiomatous endothelial cyst

KW - Hemangioma

KW - Lymphangioma

KW - Vascular malformation

KW - Vascular tumor, cyst, pseudocyst

UR - http://www.scopus.com/inward/record.url?scp=85055350282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055350282&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2018.07.013

DO - 10.1016/j.humpath.2018.07.013

M3 - Article

VL - 82

SP - 95

EP - 102

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

ER -