Best practices recommendations in the application of immunohistochemistry in urologic pathology: Report from the International Society of Urological Pathology Consensus Conference

Mahul B. Amin, Jonathan I. Epstein, Thomas M. Ulbright, Peter A. Humphrey, Lars Egevad, Rodolfo Montironi, David Grignon, Kiril Trpkov, Antonio Lopez-Beltran, Ming Zhou, Pedram Argani, Brett Delahunt, Daniel M. Berney, John R. Srigley, Satish K. Tickoo, Victor E. Reuter

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Members of the International Society of Urological Pathology (ISUP) participated in a half-day consensus conference to discuss guidelines and recommendations regarding best practice approaches to use of immunohistochemistry (IHC) in differential diagnostic situations in urologic pathology, including bladder, prostate, testis and, kidney lesions. Four working groups, selected by the ISUP leadership, identified several high-interest topics based on common or relevant challenging diagnostic situations and proposed best practice recommendations, which were discussed by the membership. The overall summary of the discussions and the consensus opinion forms the basis of a series of articles, one for each organ site. This Special Article summarizes the overall recommendations made by the four working groups. It is anticipated that this ISUP effort will be valuable to the entire practicing community in the appropriate use of IHC in diagnostic urologic pathology.

Original languageEnglish (US)
Pages (from-to)1017-1022
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume38
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • best practices
  • germ cell tumors
  • immunohistochemistry
  • ISUP recommendations
  • prostate adenocarcinoma
  • renal cell carcinoma
  • sex cord-stromal tumors
  • summary
  • urothelial carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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    Amin, M. B., Epstein, J. I., Ulbright, T. M., Humphrey, P. A., Egevad, L., Montironi, R., Grignon, D., Trpkov, K., Lopez-Beltran, A., Zhou, M., Argani, P., Delahunt, B., Berney, D. M., Srigley, J. R., Tickoo, S. K., & Reuter, V. E. (2014). Best practices recommendations in the application of immunohistochemistry in urologic pathology: Report from the International Society of Urological Pathology Consensus Conference. American Journal of Surgical Pathology, 38(8), 1017-1022. https://doi.org/10.1097/PAS.0000000000000254