Beta-adrenergic enhancement of angiotensin II-stimulated aldosterone secretion

J. Howard Pratt, James A. McAteer

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Beta-adrenergic agonists have been shown to stimulate aldosterone secretion. Angiotensin II (AII) is one of the important stimuli of aldosterone secretion; conceivably beta-adrenergic influences affect the stimulatory potential of AII. Using cultured rat adrenal capsules, we found that 10-7 M epinephrine and 10-7 M isoproterenol enhanced 10-7 M AII-stimulated aldosterone production. Propranolol (10-7 M) completely inhibited the ability of epinephrine to augment the stimulatory actions of AII. In conclusion, beta-adrenergic agonists promote stimulation of aldosterone secretion by AII.

Original languageEnglish (US)
Pages (from-to)2089-2095
Number of pages7
JournalLife Sciences
Volume44
Issue number26
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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