Beta-adrenergic enhancement of angiotensin II-stimulated aldosterone secretion

J. Howard Pratt, James A. McAteer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Beta-adrenergic agonists have been shown to stimulate aldosterone secretion. Angiotensin II (AII) is one of the important stimuli of aldosterone secretion; conceivably beta-adrenergic influences affect the stimulatory potential of AII. Using cultured rat adrenal capsules, we found that 10-7 M epinephrine and 10-7 M isoproterenol enhanced 10-7 M AII-stimulated aldosterone production. Propranolol (10-7 M) completely inhibited the ability of epinephrine to augment the stimulatory actions of AII. In conclusion, beta-adrenergic agonists promote stimulation of aldosterone secretion by AII.

Original languageEnglish
Pages (from-to)2089-2095
Number of pages7
JournalLife Sciences
Volume44
Issue number26
DOIs
StatePublished - 1989

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Aldosterone
Angiotensin II
Adrenergic Agents
Adrenergic beta-Agonists
Epinephrine
Isoproterenol
Propranolol
Capsules
Rats

ASJC Scopus subject areas

  • Pharmacology

Cite this

Beta-adrenergic enhancement of angiotensin II-stimulated aldosterone secretion. / Pratt, J. Howard; McAteer, James A.

In: Life Sciences, Vol. 44, No. 26, 1989, p. 2089-2095.

Research output: Contribution to journalArticle

Pratt, J. Howard ; McAteer, James A. / Beta-adrenergic enhancement of angiotensin II-stimulated aldosterone secretion. In: Life Sciences. 1989 ; Vol. 44, No. 26. pp. 2089-2095.
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