Beta-adrenoceptor function in human adult skin fibroblasts: a study of manic-depressive illness.

W. H. Berrettini, J. Bardakjian, A. L. Barnett, J. I. Nurnberger, E. S. Gershon

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Abstract

Catecholamine theories of affective illness provide a rationale for the study of beta-adrenoceptor function in these disorders. Skin fibroblasts were grown in tissue culture from skin biopsies of normal volunteers and manic-depressive subjects for measurement of isoprenaline-stimulated production of cyclic AMP. Monolayers of fibroblasts in wells were incubated for 3 min with or without 0.5 microM-isoprenaline. The cyclic AMP was isolated by ion-exchange chromatography and quantitated by radioimmunoassay. The isoprenaline-stimulated levels of cyclic AMP in manic-depressive subjects (n = 12) were no different from those in normal volunteers (n = 13). Thus, no evidence was found for abnormal beta-adrenoceptor function in manic-depressive illness.

Original languageEnglish (US)
Pages (from-to)30-41
Number of pages12
JournalCiba Foundation symposium
Volume123
StatePublished - Dec 1 1986
Externally publishedYes

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