Beta-adrenoceptor function in human adult skin fibroblasts

a study of manic-depressive illness.

W. H. Berrettini, J. Bardakjian, A. L. Barnett, John Nurnberger, E. S. Gershon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Catecholamine theories of affective illness provide a rationale for the study of beta-adrenoceptor function in these disorders. Skin fibroblasts were grown in tissue culture from skin biopsies of normal volunteers and manic-depressive subjects for measurement of isoprenaline-stimulated production of cyclic AMP. Monolayers of fibroblasts in wells were incubated for 3 min with or without 0.5 microM-isoprenaline. The cyclic AMP was isolated by ion-exchange chromatography and quantitated by radioimmunoassay. The isoprenaline-stimulated levels of cyclic AMP in manic-depressive subjects (n = 12) were no different from those in normal volunteers (n = 13). Thus, no evidence was found for abnormal beta-adrenoceptor function in manic-depressive illness.

Original languageEnglish
Pages (from-to)30-41
Number of pages12
JournalCIBA Foundation Symposia
Volume123
StatePublished - 1986
Externally publishedYes

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Isoproterenol
Cyclic AMP
Adrenergic Receptors
Fibroblasts
Skin
Healthy Volunteers
Ion Exchange Chromatography
Catecholamines
Radioimmunoassay
Biopsy
Major Affective Disorder 2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Berrettini, W. H., Bardakjian, J., Barnett, A. L., Nurnberger, J., & Gershon, E. S. (1986). Beta-adrenoceptor function in human adult skin fibroblasts: a study of manic-depressive illness. CIBA Foundation Symposia, 123, 30-41.

Beta-adrenoceptor function in human adult skin fibroblasts : a study of manic-depressive illness. / Berrettini, W. H.; Bardakjian, J.; Barnett, A. L.; Nurnberger, John; Gershon, E. S.

In: CIBA Foundation Symposia, Vol. 123, 1986, p. 30-41.

Research output: Contribution to journalArticle

Berrettini, W. H. ; Bardakjian, J. ; Barnett, A. L. ; Nurnberger, John ; Gershon, E. S. / Beta-adrenoceptor function in human adult skin fibroblasts : a study of manic-depressive illness. In: CIBA Foundation Symposia. 1986 ; Vol. 123. pp. 30-41.
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