Beta blockers and the primary prevention of nonfatal myocardial infarction in patients with high blood pressure

Bruce M. Psaty, Thomas D. Koepsell, Edward H. Wagner, James P. LoGerfo, Thomas S. Inui

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A population-based, case-control study was conducted to determine whether β blockers, used for the treatment of high blood pressure, prevent first events of coronary heart disease. All study subjects were health-maintenance organization enrollees with pharmacologically treated hypertension. Patients presented in 1982 to 1984 with new coronary heart disease, and control subjects were a probability sample of eligible hypertensive enrollees free of coronary heart disease. With the investigators blind to case-control status, the subjects' medical records were reviewed for other coronary risk factors, and the health-maintenance organization's computerized pharmacy database was used to ascertain the use of β blockers. A larger proportion of controls than cases were using β blockers. This difference was confined to the subgroup with nonfatal myocardial infarctions. For current use, the estimated relative risk for nonfatal myocardial infarction was 0.62 (95% confidence interval, 0.39 to 0.99). Among current users of β blockers, higher doses conferred greater protection. Past use and total lifetime intake of β blockers were only weakly associated with case-control status. The current use of β blockers may prevent first events of nonfatal myocardial infarction in patients with high blood pressure.

Original languageEnglish (US)
Pages (from-to)G12-G14
JournalThe American journal of cardiology
Volume66
Issue number16
DOIs
StatePublished - Nov 6 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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