Beta–adrenergic receptors on lymphoblasts: A study of manic–depressive illness

Wade H. Berrettini, Charles B. Cappellari, John I. Nurnberger, Elliot S. Gershon

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Beta–adrenergic receptor function has been the subject of much research in manic–depressive illness. Lymphoblast beta receptor binding was analyzed by Scatchard plot, using cell lines establishedfrom 17 unrelated bipolar subjects and 14 normals. No significant differences in affinity or density of beta receptors were found, in contrast to a previous report. Both the affinity and density of receptors appeared obe a stable characteristic of a cell line, as determined by repeated assay of the same cell lines.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalNeuropsychobiology
Volume17
Issue number1-2
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Keywords

  • Beta-adrenergic receptors
  • Lymphoblasts
  • Manic-depressive illness

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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