Bicalutamide 50 mg monotherapy in patients with isolated high-grade PIN

Findings in repeat biopsies at 6 months

Aldo V. Bono, Roberta Mazzucchelli, Ilaria Ferrari, Antonio Lopez-Beltran, Andrea B. Galosi, Liang Cheng, Rodolfo Montironi

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Abstract

Objectives: To evaluate morphological findings in repeat biopsies in patients with isolated high-grade prostatic intraepithelial neoplasia (HGPIN) after a 6-month course of bicalutamide (Casodex) 50 mg/day. Methods: 20 consecutive patients with isolated HGPIN in prostate biopsies were treated for 6 months with bicalutamide 50 mg/day. After treatment, the patients were resubmitted to prostate biopsy mapping. The control group included 22 untreated consecutive patients with isolated high-grade PIN with repeat biopsies taken 6 months after the initial biopsies. Results: In the initial biopsies of the treated group, HGPIN was monofocal in 12 patients and plurifocal in 8. In the repeat biopsies HGPIN was present in 2 patients, monofocal in both, whereas prostate adenocarcinoma (PCa) was discovered in one. In the control group, HGPIN was monofocal in 15 and plurifocal in 7. In the repeat biopsies HGPIN was present in six patients, being monofocal in three and plurifocal in the other three. PCa was present in one. Conclusions: There was a lower incidence of HGPIN (treated group vs control: 10% vs 27.2%) after 6 months of bicalutamide. Reduction in its extent was also observed (treated group vs control: monofocal 100% vs 50%). Treatment did not affect the incidence of cancer (treated vs control: 5% vs 4.5%).

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalJournal of Clinical Pathology
Volume60
Issue number4
DOIs
StatePublished - Apr 2007

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Prostatic Intraepithelial Neoplasia
Biopsy
Prostate
Control Groups
Adenocarcinoma
bicalutamide
Incidence
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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Bicalutamide 50 mg monotherapy in patients with isolated high-grade PIN : Findings in repeat biopsies at 6 months. / Bono, Aldo V.; Mazzucchelli, Roberta; Ferrari, Ilaria; Lopez-Beltran, Antonio; Galosi, Andrea B.; Cheng, Liang; Montironi, Rodolfo.

In: Journal of Clinical Pathology, Vol. 60, No. 4, 04.2007, p. 443-446.

Research output: Contribution to journalArticle

Bono, Aldo V. ; Mazzucchelli, Roberta ; Ferrari, Ilaria ; Lopez-Beltran, Antonio ; Galosi, Andrea B. ; Cheng, Liang ; Montironi, Rodolfo. / Bicalutamide 50 mg monotherapy in patients with isolated high-grade PIN : Findings in repeat biopsies at 6 months. In: Journal of Clinical Pathology. 2007 ; Vol. 60, No. 4. pp. 443-446.
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N2 - Objectives: To evaluate morphological findings in repeat biopsies in patients with isolated high-grade prostatic intraepithelial neoplasia (HGPIN) after a 6-month course of bicalutamide (Casodex) 50 mg/day. Methods: 20 consecutive patients with isolated HGPIN in prostate biopsies were treated for 6 months with bicalutamide 50 mg/day. After treatment, the patients were resubmitted to prostate biopsy mapping. The control group included 22 untreated consecutive patients with isolated high-grade PIN with repeat biopsies taken 6 months after the initial biopsies. Results: In the initial biopsies of the treated group, HGPIN was monofocal in 12 patients and plurifocal in 8. In the repeat biopsies HGPIN was present in 2 patients, monofocal in both, whereas prostate adenocarcinoma (PCa) was discovered in one. In the control group, HGPIN was monofocal in 15 and plurifocal in 7. In the repeat biopsies HGPIN was present in six patients, being monofocal in three and plurifocal in the other three. PCa was present in one. Conclusions: There was a lower incidence of HGPIN (treated group vs control: 10% vs 27.2%) after 6 months of bicalutamide. Reduction in its extent was also observed (treated group vs control: monofocal 100% vs 50%). Treatment did not affect the incidence of cancer (treated vs control: 5% vs 4.5%).

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