BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11

Kun Wang, Xiao Ming Yin, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Catherine L. Keck, Drazen B. Zimonjic, Nicholas C. Popescu, Stanley J. Korsmeyer

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Abstract

BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single α-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalGenomics
Volume53
Issue number2
DOIs
StatePublished - Oct 15 1998

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ASJC Scopus subject areas

  • Genetics

Cite this

Wang, K., Yin, X. M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Keck, C. L., Zimonjic, D. B., Popescu, N. C., & Korsmeyer, S. J. (1998). BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11. Genomics, 53(2), 235-238. https://doi.org/10.1006/geno.1998.5489