Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men

Emma Childs, Sean O'Connor, Harriet de Wit

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: The biological mechanisms by which acute stress increases alcohol consumption are unclear. One potential mechanism is that stress acts by altering the pharmacological and subjective effects of alcohol. Acute stress produces a cascade of physiological and psychological effects, each with a distinctive time course. In this study, we investigated whether different phases of response to an acute stress alter the subjective effects of intravenous alcohol, by administering the drug at 2 different times after the stress. Methods: Healthy men (n=25) participated in 2 sessions: 1 with the Trier Social Stress Test and the other with a nonstressful control task, each followed by infusions of intravenous alcohol (targeting 40mg% in 5minutes) and placebo. One group of participants received alcohol within 1minute of completing the tasks (Alc0, n=11), followed by placebo 30minutes later. In the other group (Alc30, n=14), the order of alcohol and placebo infusions was reversed. Subjective effects (i.e., anxiety, stimulation, want more) and physiological measures (heart rate, blood pressure, salivary cortisol) were measured before and at repeated intervals after the tasks and infusions. Results: Stress did not change the subjective effects of alcohol in either group. However, when individual differences in alcohol responses were considered, stress differentially altered the stimulant-like and sedative effects of alcohol. Among individuals who exhibited predominantly stimulant responses to alcohol in the nonstressful condition, stress decreased the stimulant-like effects of alcohol and "wanting more." By contrast, among participants who did not report stimulation after alcohol in the control session, stress decreased the sedative effects and increased "want more." In addition, alcohol administered immediately after the Trier Social Stress Test dampened cortisol responses yet prolonged negative subjective responses to the stress. Conclusions: These findings demonstrate that there are bidirectional relationships between alcohol and stress. Alcohol influences responses to stress, and stress changes reactions to alcohol, depending on an individual's pattern of response to alcohol. This study highlights the fact that stress-alcohol interactions vary among individual drinkers, suggesting that the effects of stress on motivation to drink alcohol may also differ between individuals.

Original languageEnglish
Pages (from-to)1794-1803
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume35
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Alcohols
Placebos
Hypnotics and Sedatives
Exercise Test
Hydrocortisone
Acute-Phase Reaction
Blood pressure
Intravenous Infusions
Individuality
Alcohol Drinking
Motivation
Anxiety
Heart Rate
Pharmacology
Psychology
Blood Pressure

Keywords

  • Acute stress
  • Alcohol
  • Anxiety
  • Cortisol
  • Trier social stress test

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men. / Childs, Emma; O'Connor, Sean; de Wit, Harriet.

In: Alcoholism: Clinical and Experimental Research, Vol. 35, No. 10, 10.2011, p. 1794-1803.

Research output: Contribution to journalArticle

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