Bidirectional selection for susceptibility to ethanol withdrawal seizures in Mus musculus

John C. Crabbe, Ann Kosobud, Emmett R. Young, Brenda R. Tam, John D. McSwigan

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Using within-family selection from a genetically heterogeneous population of HS/Ibg mice, lines and replicates have been selected for high (withdrawal seizure prone; WSP) and low (withdrawal seizure resistant; WSR) susceptibility to convulsions after withdrawal from chronic exposure to ethanol. Two nonselected control lines (withdrawal-seizure control; WSC) have also been maintained. The response was bidirectional in both replicates across 11 selected generations, WSP and WSR lines differing approximately 10-fold in seizure severity after an identical regimen of chronic exposure to ethanol. Realized heritability was found to be approximately 0.28. The phenotype appears to be polygenic in nature. The relatively low amount of inbreeding in these lines and the large response to selection should make them useful for examining the physiological basis of physical dependence on ethanol.

Original languageEnglish (US)
Pages (from-to)521-536
Number of pages16
JournalBehavior Genetics
Volume15
Issue number6
DOIs
StatePublished - Nov 1985
Externally publishedYes

Fingerprint

Mus musculus
seizures
ethanol
Seizures
Ethanol
chronic exposure
heritability
inbreeding
Inbreeding
phenotype
fold
seizure
Phenotype
mice
Population
exposure

Keywords

  • alcoholism
  • ethanol physical dependence
  • ethanol withdrawal
  • handling-induced convulsions
  • mice
  • pharmacogenetics
  • selective breeding
  • withdrawal seizure-prone (WSP) and withdrawal seizure-resistant (WSR) lines

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

Bidirectional selection for susceptibility to ethanol withdrawal seizures in Mus musculus. / Crabbe, John C.; Kosobud, Ann; Young, Emmett R.; Tam, Brenda R.; McSwigan, John D.

In: Behavior Genetics, Vol. 15, No. 6, 11.1985, p. 521-536.

Research output: Contribution to journalArticle

Crabbe, John C. ; Kosobud, Ann ; Young, Emmett R. ; Tam, Brenda R. ; McSwigan, John D. / Bidirectional selection for susceptibility to ethanol withdrawal seizures in Mus musculus. In: Behavior Genetics. 1985 ; Vol. 15, No. 6. pp. 521-536.
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