Bile salt diarrhea

Bruce Robb, Jeffrey B. Matthews

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Alterations in bile acid metabolism and in the enterohepatic circulation are often associated with chronic diarrhea and should be considered when more common causes of chronic diarrhea have been excluded. Bile acid diarrhea most often occurs in disease or resection of the terminal ileum, in which there is increased exposure of the colonic mucosa to bile salts with consequent activation of fluid and electrolyte secretion. Congenital or acquired defects in the enterohepatic circulation of bile acids also may lead to diarrhea. Although multiple diagnostic tests may be considered to confirm abnormal fecal bile acid losses, the most critical elements of the clinical evaluation of suspected bile acid diarrhea are a careful history to exclude more common causes of chronic diarrhea and a diagnostic trial of bile acid-binding resins.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalCurrent Gastroenterology Reports
Volume7
Issue number5
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Bile Acids and Salts
Diarrhea
Enterohepatic Circulation
Fluids and Secretions
Ileum
Routine Diagnostic Tests
Electrolytes
Mucous Membrane
History

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Robb, B., & Matthews, J. B. (2005). Bile salt diarrhea. Current Gastroenterology Reports, 7(5), 379-383.

Bile salt diarrhea. / Robb, Bruce; Matthews, Jeffrey B.

In: Current Gastroenterology Reports, Vol. 7, No. 5, 10.2005, p. 379-383.

Research output: Contribution to journalArticle

Robb, B & Matthews, JB 2005, 'Bile salt diarrhea', Current Gastroenterology Reports, vol. 7, no. 5, pp. 379-383.
Robb B, Matthews JB. Bile salt diarrhea. Current Gastroenterology Reports. 2005 Oct;7(5):379-383.
Robb, Bruce ; Matthews, Jeffrey B. / Bile salt diarrhea. In: Current Gastroenterology Reports. 2005 ; Vol. 7, No. 5. pp. 379-383.
@article{e6149f7276624ad1bea59bbc4ba7d50a,
title = "Bile salt diarrhea",
abstract = "Alterations in bile acid metabolism and in the enterohepatic circulation are often associated with chronic diarrhea and should be considered when more common causes of chronic diarrhea have been excluded. Bile acid diarrhea most often occurs in disease or resection of the terminal ileum, in which there is increased exposure of the colonic mucosa to bile salts with consequent activation of fluid and electrolyte secretion. Congenital or acquired defects in the enterohepatic circulation of bile acids also may lead to diarrhea. Although multiple diagnostic tests may be considered to confirm abnormal fecal bile acid losses, the most critical elements of the clinical evaluation of suspected bile acid diarrhea are a careful history to exclude more common causes of chronic diarrhea and a diagnostic trial of bile acid-binding resins.",
author = "Bruce Robb and Matthews, {Jeffrey B.}",
year = "2005",
month = "10",
language = "English (US)",
volume = "7",
pages = "379--383",
journal = "Current Gastroenterology Reports",
issn = "1522-8037",
publisher = "Current Medicine Group",
number = "5",

}

TY - JOUR

T1 - Bile salt diarrhea

AU - Robb, Bruce

AU - Matthews, Jeffrey B.

PY - 2005/10

Y1 - 2005/10

N2 - Alterations in bile acid metabolism and in the enterohepatic circulation are often associated with chronic diarrhea and should be considered when more common causes of chronic diarrhea have been excluded. Bile acid diarrhea most often occurs in disease or resection of the terminal ileum, in which there is increased exposure of the colonic mucosa to bile salts with consequent activation of fluid and electrolyte secretion. Congenital or acquired defects in the enterohepatic circulation of bile acids also may lead to diarrhea. Although multiple diagnostic tests may be considered to confirm abnormal fecal bile acid losses, the most critical elements of the clinical evaluation of suspected bile acid diarrhea are a careful history to exclude more common causes of chronic diarrhea and a diagnostic trial of bile acid-binding resins.

AB - Alterations in bile acid metabolism and in the enterohepatic circulation are often associated with chronic diarrhea and should be considered when more common causes of chronic diarrhea have been excluded. Bile acid diarrhea most often occurs in disease or resection of the terminal ileum, in which there is increased exposure of the colonic mucosa to bile salts with consequent activation of fluid and electrolyte secretion. Congenital or acquired defects in the enterohepatic circulation of bile acids also may lead to diarrhea. Although multiple diagnostic tests may be considered to confirm abnormal fecal bile acid losses, the most critical elements of the clinical evaluation of suspected bile acid diarrhea are a careful history to exclude more common causes of chronic diarrhea and a diagnostic trial of bile acid-binding resins.

UR - http://www.scopus.com/inward/record.url?scp=28244462446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28244462446&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 379

EP - 383

JO - Current Gastroenterology Reports

JF - Current Gastroenterology Reports

SN - 1522-8037

IS - 5

ER -