Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma

Attila Nakeeb, Pamela A. Lipsett, Keith D. Lillemoe, Mary K. Fox-Talbot, JoAnn Coleman, John L. Cameron, Henry A. Pitt

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Abstract

BACKGROUND: Cholangiocarcinoma develops in 5% to 15% of patients with choledochal cysts, sclerosing cholangitis, and intrahepatic stones. The detection of cholangiocarcinoma in patients with premalignant biliary conditions has been difficult. Serum levels of carcinoembryonic antigen (CEA) have been neither sensitive nor specific for the diagnosis of cholangiocarcinoma. However, CEA has been shown to be present in cholangiocarcinomas by immunohistochemical staining. Therefore, we measured the level of CEA excreted in bile in patients with benign strictures, premalignant biliary diseases, and cholangiocarcinoma. PATIENTS AND METHODS: Bile was obtained from transhepatic stents in patients with benign biliary strictures (34), choledochal cysts (5), primary sclerosing cholangitis (6), intrahepatic cholelithiasis (5), and perihilar cholangiocarcinoma (25). Samples were analyzed for CEA using a solid phase, two-site immunoenzymetric assay. RESULTS: Biliary CEA levels were significantly elevated (P

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalAmerican Journal of Surgery
Volume171
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

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Cholangiocarcinoma
Carcinoembryonic Antigen
Choledochal Cyst
Sclerosing Cholangitis
Bile
Pathologic Constriction
Klatskin Tumor
Cholelithiasis
Stents
Staining and Labeling
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Nakeeb, A., Lipsett, P. A., Lillemoe, K. D., Fox-Talbot, M. K., Coleman, J., Cameron, J. L., & Pitt, H. A. (1996). Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma. American Journal of Surgery, 171(1), 147-152. https://doi.org/10.1016/S0002-9610(99)80090-7

Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma. / Nakeeb, Attila; Lipsett, Pamela A.; Lillemoe, Keith D.; Fox-Talbot, Mary K.; Coleman, JoAnn; Cameron, John L.; Pitt, Henry A.

In: American Journal of Surgery, Vol. 171, No. 1, 01.1996, p. 147-152.

Research output: Contribution to journalArticle

Nakeeb, A, Lipsett, PA, Lillemoe, KD, Fox-Talbot, MK, Coleman, J, Cameron, JL & Pitt, HA 1996, 'Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma', American Journal of Surgery, vol. 171, no. 1, pp. 147-152. https://doi.org/10.1016/S0002-9610(99)80090-7
Nakeeb, Attila ; Lipsett, Pamela A. ; Lillemoe, Keith D. ; Fox-Talbot, Mary K. ; Coleman, JoAnn ; Cameron, John L. ; Pitt, Henry A. / Biliary carcinoembryonic antigen levels are a marker for cholangiocarcinoma. In: American Journal of Surgery. 1996 ; Vol. 171, No. 1. pp. 147-152.
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AU - Cameron, John L.

AU - Pitt, Henry A.

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AB - BACKGROUND: Cholangiocarcinoma develops in 5% to 15% of patients with choledochal cysts, sclerosing cholangitis, and intrahepatic stones. The detection of cholangiocarcinoma in patients with premalignant biliary conditions has been difficult. Serum levels of carcinoembryonic antigen (CEA) have been neither sensitive nor specific for the diagnosis of cholangiocarcinoma. However, CEA has been shown to be present in cholangiocarcinomas by immunohistochemical staining. Therefore, we measured the level of CEA excreted in bile in patients with benign strictures, premalignant biliary diseases, and cholangiocarcinoma. PATIENTS AND METHODS: Bile was obtained from transhepatic stents in patients with benign biliary strictures (34), choledochal cysts (5), primary sclerosing cholangitis (6), intrahepatic cholelithiasis (5), and perihilar cholangiocarcinoma (25). Samples were analyzed for CEA using a solid phase, two-site immunoenzymetric assay. RESULTS: Biliary CEA levels were significantly elevated (P

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