Bimatoprost/timolol fixed combination: A 3-month double-masked, randomized parallel comparison to its individual components in patients with glaucoma or ocular hypertension

James D. Brandt, Louis Cantor, L. Jay Katz, Amy L. Batoosingh, Connie Chou, Izabella Bossowska

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

PURPOSE: To evaluate the safety and efficacy of a fixed combination (FC) of bimatoprost (BIM) and timolol (TIM) compared with each of the active components for 3 months. PATIENTS AND METHODS: Two double-masked, randomized, multicenter parallel studies of FC (once-daily, mornings), BIM (once-daily, evenings), or TIM (twice-daily) were conducted in 1061 patients with glaucoma or ocular hypertension. RESULTS: Mean diurnal decreases from baseline intraocular pressure (IOP) at month 3 were 8.1, 7.9, and 6.4 mm Hg for the FC, BIM, and TIM groups, respectively. The proportion of patients with a mean diurnal percent reduction from baseline in IOP of more than 20% across all visits was 81.8% (436/533), 72.1% (191/265), and 49.8% (131/263) for the FC, BIM, and TIM groups, respectively (P

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalJournal of Glaucoma
Volume17
Issue number3
DOIs
StatePublished - Apr 2008
Externally publishedYes

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Timolol
Ocular Hypertension
Glaucoma
Intraocular Pressure
Multicenter Studies
Safety
Bimatoprost

Keywords

  • Bimatoprost
  • Fixed combination
  • Glaucoma
  • Intraocular pressure
  • Timolol

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bimatoprost/timolol fixed combination : A 3-month double-masked, randomized parallel comparison to its individual components in patients with glaucoma or ocular hypertension. / Brandt, James D.; Cantor, Louis; Katz, L. Jay; Batoosingh, Amy L.; Chou, Connie; Bossowska, Izabella.

In: Journal of Glaucoma, Vol. 17, No. 3, 04.2008, p. 211-216.

Research output: Contribution to journalArticle

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