Binding of Haemophilus ducreyi to extracellular matrix proteins

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We developed an enzyme-linked immunosorbent assay-based assay to assess Haemophilus ducreyi binding to extracellular matrix (ECM) proteins. H. ducreyi 35000HP bound to fibronectin, laminin, and type I and III collagen but not to type IV, V, or VI collagen or elastin. Isogenic strains with mutations in ftp A or losB bound as well as the parent, suggesting that neither pili nor full-length lipooligosaccharide is required for H. ducreyi to bind to ECM proteins.

Original languageEnglish (US)
Pages (from-to)2649-2653
Number of pages5
JournalInfection and immunity
Volume67
Issue number5
DOIs
StatePublished - May 1999

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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