Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia

J. D. Woolley, M. L. Gorno-Tempini, W. W. Seeley, K. Rankin, S. S. Lee, Brandy Matthews, B. L. Miller

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

BACKGROUND: Neurophysiologic studies on human and nonhuman primates implicate an orbitofrontal-insular-striatal circuit in high-level regulation of feeding. However, the role of these areas in determining feeding disturbances in neurologic patients remains uncertain. OBJECTIVE AND METHODS: To determine brain structures critical for control of eating behavior, we performed a prospective, laboratory-based, free-feeding study of 18 healthy control subjects and 32 patients with neurodegenerative disease. MR voxel-based morphometry (VBM) was used to identify regions of significant atrophy in patients who overate compared with those who did not. RESULTS: Despite normal taste recognition, 6 of 32 patients compulsively binged, consuming large quantities of food after reporting appropriate satiety. All six patients who overate were clinically diagnosed with frontotemporal dementia (FTD), a disorder previously associated with disordered eating, while the nonovereaters were diagnosed with FTD, semantic dementia, progressive aphasia, progressive supranuclear palsy, and Alzheimer disease. VBM revealed that binge-eating patients had significantly greater atrophy in the right ventral insula, striatum, and orbitofrontal cortex. CONCLUSION: Binge eating can occur despite reported satiety and is associated with damage to a right-sided orbitofrontal-insular-striatal circuit in humans. These findings support a model in which ventral insular and orbitofrontal cortices serve as higher-order gustatory regions and cooperate with the striatum to guide appropriate feeding responses.

Original languageEnglish (US)
Pages (from-to)1424-1433
Number of pages10
JournalNeurology
Volume69
Issue number14
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Corpus Striatum
Frontotemporal Dementia
Bulimia
Atrophy
Prefrontal Cortex
Progressive Supranuclear Palsy
Aphasia
Feeding Behavior
Neurodegenerative Diseases
Cerebral Cortex
Primates
Nervous System
Healthy Volunteers
Alzheimer Disease
Eating
Food
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Woolley, J. D., Gorno-Tempini, M. L., Seeley, W. W., Rankin, K., Lee, S. S., Matthews, B., & Miller, B. L. (2007). Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia. Neurology, 69(14), 1424-1433. https://doi.org/10.1212/01.wnl.0000277461.06713.23

Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia. / Woolley, J. D.; Gorno-Tempini, M. L.; Seeley, W. W.; Rankin, K.; Lee, S. S.; Matthews, Brandy; Miller, B. L.

In: Neurology, Vol. 69, No. 14, 10.2007, p. 1424-1433.

Research output: Contribution to journalArticle

Woolley, JD, Gorno-Tempini, ML, Seeley, WW, Rankin, K, Lee, SS, Matthews, B & Miller, BL 2007, 'Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia', Neurology, vol. 69, no. 14, pp. 1424-1433. https://doi.org/10.1212/01.wnl.0000277461.06713.23
Woolley, J. D. ; Gorno-Tempini, M. L. ; Seeley, W. W. ; Rankin, K. ; Lee, S. S. ; Matthews, Brandy ; Miller, B. L. / Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia. In: Neurology. 2007 ; Vol. 69, No. 14. pp. 1424-1433.
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