Bioactive glass in tissue engineering

Mohamed N. Rahaman, Delbert E. Day, B. Sonny Bal, Qiang Fu, Steven B. Jung, Lynda F. Bonewald, Antoni P. Tomsia

Research output: Contribution to journalReview article

910 Scopus citations

Abstract

This review focuses on recent advances in the development and use of bioactive glass for tissue engineering applications. Despite its inherent brittleness, bioactive glass has several appealing characteristics as a scaffold material for bone tissue engineering. New bioactive glasses based on borate and borosilicate compositions have shown the ability to enhance new bone formation when compared to silicate bioactive glass. Borate-based bioactive glasses also have controllable degradation rates, so the degradation of the bioactive glass implant can be more closely matched to the rate of new bone formation. Bioactive glasses can be doped with trace quantities of elements such as Cu, Zn and Sr, which are known to be beneficial for healthy bone growth. In addition to the new bioactive glasses, recent advances in biomaterials processing have resulted in the creation of scaffold architectures with a range of mechanical properties suitable for the substitution of loaded as well as non-loaded bone. While bioactive glass has been extensively investigated for bone repair, there has been relatively little research on the application of bioactive glass to the repair of soft tissues. However, recent work has shown the ability of bioactive glass to promote angiogenesis, which is critical to numerous applications in tissue regeneration, such as neovascularization for bone regeneration and the healing of soft tissue wounds. Bioactive glass has also been shown to enhance neocartilage formation during in vitro culture of chondrocyte-seeded hydrogels, and to serve as a subchondral substrate for tissue-engineered osteochondral constructs. Methods used to manipulate the structure and performance of bioactive glass in these tissue engineering applications are analyzed.

Original languageEnglish (US)
Pages (from-to)2355-2373
Number of pages19
JournalActa Biomaterialia
Volume7
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Keywords

  • Angiogenesis
  • Bioactive glass
  • Bone repair
  • Soft tissue repair
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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  • Cite this

    Rahaman, M. N., Day, D. E., Sonny Bal, B., Fu, Q., Jung, S. B., Bonewald, L. F., & Tomsia, A. P. (2011). Bioactive glass in tissue engineering. Acta Biomaterialia, 7(6), 2355-2373. https://doi.org/10.1016/j.actbio.2011.03.016