Bioactive sphingolipids in the pathogenesis of chronic obstructive pulmonary disease

Kengo Koike, Evgeny V. Berdyshev, Russell P. Bowler, April K. Scruggs, Danting Cao, Kelly S. Schweitzer, Karina A. Serban, Irina Petrache

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A better understanding of the pathogenesis of distinct chronic obstructive pulmonary disease (COPD) phenotypes will improve diagnostic and therapeutic options for this common disease. We present evidence that sphingolipids such as ceramides are involved in the emphysema pathogenesis. Whereas distinct ceramide species cause cell death by apoptosis and necroptosis, cell adaptation leads to accumulation of other sphingolipid metabolites that extend cell survival by triggering autophagy. Cigarette smoke-released sphingolipids have been involved in both the initiation and persistence of lung injury via intracellular signaling and paracrine effects mediated via exosomes and plasma membrane-bound microparticles. Strategies to control sphingolipid metabolite production may promote cellular repair and maintenance to treat COPD.

Original languageEnglish (US)
Pages (from-to)S249-S252
JournalAnnals of the American Thoracic Society
Volume15
DOIs
StatePublished - Dec 2018
Externally publishedYes

Keywords

  • Ceramide
  • Emphysema
  • Sphingosine-1 phosphate

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Bioactive sphingolipids in the pathogenesis of chronic obstructive pulmonary disease'. Together they form a unique fingerprint.

  • Cite this

    Koike, K., Berdyshev, E. V., Bowler, R. P., Scruggs, A. K., Cao, D., Schweitzer, K. S., Serban, K. A., & Petrache, I. (2018). Bioactive sphingolipids in the pathogenesis of chronic obstructive pulmonary disease. Annals of the American Thoracic Society, 15, S249-S252. https://doi.org/10.1513/AnnalsATS.201809-592MG