Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2

Jian-Ting Zhang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

ABCG2 is a half ATP-binding cassette (ABC) transporter that facilitates efflux of a wide variety of substrates ranging from natural products to synthetic anticancer drugs. Over-expression of ABCG2 has been shown to cause multidrug resistance in both laboratory model cell lines and in clinical settings. The polymorphism in ABCG2 has also been suggested to affect the function and clinical outcome in cancer patients. More recently, ABCG2 has been suggested to play a protective role for cancer and normal stem cells. Thus, ABCG2 is an ideal target for therapeutic development to chemosensitize drug resistant cancers. In this paper, the recent progress on understanding the structure, function, and pharmacology of ABCG2 and its role in drug resistance and cancer stem cells will be reviewed.

Original languageEnglish
Pages (from-to)531-541
Number of pages11
JournalJournal of Central South University (Medical Sciences)
Volume32
Issue number4
StatePublished - Aug 2007

Fingerprint

MDR Genes
Neoplastic Stem Cells
Biochemistry
Pharmacology
ATP-Binding Cassette Transporters
Multiple Drug Resistance
Biological Products
Drug Resistance
Pharmaceutical Preparations
Neoplasms
Cell Line
Therapeutics

Keywords

  • ABC transporter
  • ABCG2
  • BCRP
  • Drug resistance
  • Multidrug resistance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2. / Zhang, Jian-Ting.

In: Journal of Central South University (Medical Sciences), Vol. 32, No. 4, 08.2007, p. 531-541.

Research output: Contribution to journalArticle

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