Biodegradable microfabricated plug-filters for glaucoma drainage devices

Teimour Maleki, Girish Chitnis, Jun Hyeong Park, Louis B. Cantor, Babak Ziaie

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We report on the development of a batch fabricated biodegradable truncated-cone-shaped plug filter to overcome the postoperative hypotony in nonvalved glaucoma drainage devices. Plug filters are composed of biodegradable polymers that disappear once wound healing and bleb formation has progressed past the stage where hypotony from overfiltration may cause complications in the human eye. The biodegradable nature of device eliminates the risks associated with permanent valves that may become blocked or influence the aqueous fluid flow rate in the long term. The plug-filter geometry simplifies its integration with commercial shunts. Aqueous humor outflow regulation is achieved by controlling the diameter of a laser-drilled through-hole. The batch compatible fabrication involves a modified SU-8 molding to achieve truncated-cone-shaped pillars, polydimethylsiloxane micromolding, and hot embossing of biodegradable polymers. The developed plug filter is 500m long with base and apex plane diameters of 500 and 300m, respectively, and incorporates a laser-drilled through-hole with 44-m effective diameter in the center.

Original languageEnglish (US)
Article number2179031
Pages (from-to)1507-1513
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number6
DOIs
StatePublished - May 28 2012

Keywords

  • Biodegradable plug-filter
  • glaucoma drainage device (GDD)
  • hot embossing
  • laser drilling
  • micromolding

ASJC Scopus subject areas

  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Biodegradable microfabricated plug-filters for glaucoma drainage devices'. Together they form a unique fingerprint.

  • Cite this