Biodegradable microfabricated plug-filters for glaucoma drainage devices

Teimour Maleki, Girish Chitnis, Jun Hyeong Park, Louis Cantor, Babak Ziaie

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report on the development of a batch fabricated biodegradable truncated-cone-shaped plug filter to overcome the postoperative hypotony in nonvalved glaucoma drainage devices. Plug filters are composed of biodegradable polymers that disappear once wound healing and bleb formation has progressed past the stage where hypotony from overfiltration may cause complications in the human eye. The biodegradable nature of device eliminates the risks associated with permanent valves that may become blocked or influence the aqueous fluid flow rate in the long term. The plug-filter geometry simplifies its integration with commercial shunts. Aqueous humor outflow regulation is achieved by controlling the diameter of a laser-drilled through-hole. The batch compatible fabrication involves a modified SU-8 molding to achieve truncated-cone-shaped pillars, polydimethylsiloxane micromolding, and hot embossing of biodegradable polymers. The developed plug filter is 500m long with base and apex plane diameters of 500 and 300m, respectively, and incorporates a laser-drilled through-hole with 44-m effective diameter in the center.

Original languageEnglish
Article number2179031
Pages (from-to)1507-1513
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number6
DOIs
StatePublished - 2012

Fingerprint

Biodegradable polymers
Drainage
Cones
Lasers
Polydimethylsiloxane
Molding
Flow of fluids
Flow rate
Fabrication
Geometry

Keywords

  • Biodegradable plug-filter
  • glaucoma drainage device (GDD)
  • hot embossing
  • laser drilling
  • micromolding

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Biodegradable microfabricated plug-filters for glaucoma drainage devices. / Maleki, Teimour; Chitnis, Girish; Hyeong Park, Jun; Cantor, Louis; Ziaie, Babak.

In: IEEE Transactions on Biomedical Engineering, Vol. 59, No. 6, 2179031, 2012, p. 1507-1513.

Research output: Contribution to journalArticle

Maleki, Teimour ; Chitnis, Girish ; Hyeong Park, Jun ; Cantor, Louis ; Ziaie, Babak. / Biodegradable microfabricated plug-filters for glaucoma drainage devices. In: IEEE Transactions on Biomedical Engineering. 2012 ; Vol. 59, No. 6. pp. 1507-1513.
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