Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo

Michael R. Kilbourn, James E. Carey, Robert A. Koeppe, Michael S. Haka, Gary Hutchins, Phil S. Sherman, David E. Kuhl

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The in vivo charactersitics of a new radiotracer, [18F]GBR 13119, have been examined. Full body biodistribution in rats has been determined and the expected human dosimetry calculated. Pharmacological specificity of in vivo regional brain distribution in rats was examined. Blockage of specific binding was accomplished by dopamine reuptake inhibitors but no effect was observed for pretreatment with serotonin or norepinephrine reuptake inhibitors. Preliminary examination of rat blood shows the presence of radiolabeled metabolites, which can be rapidly identified using bonded-phase (Sep-Pak) chromatography. Finally, the striatum of living primates has been imaged using PET and i.v. administration of [18F]GBR 13119. These results represent the intermediate steps in the development of [18F]GBR 13119 as a radiotracer for the study of the dopamine uptake system in man.

Original languageEnglish (US)
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume16
Issue number6
DOIs
StatePublished - 1989
Externally publishedYes

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Haplorhini
Dopamine
Dopamine Uptake Inhibitors
Primates
Chromatography
Pharmacology
Brain
GBR 13119
Serotonin and Noradrenaline Reuptake Inhibitors

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Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo. / Kilbourn, Michael R.; Carey, James E.; Koeppe, Robert A.; Haka, Michael S.; Hutchins, Gary; Sherman, Phil S.; Kuhl, David E.

In: International Journal of Radiation Applications and Instrumentation., Vol. 16, No. 6, 1989.

Research output: Contribution to journalArticle

Kilbourn, Michael R. ; Carey, James E. ; Koeppe, Robert A. ; Haka, Michael S. ; Hutchins, Gary ; Sherman, Phil S. ; Kuhl, David E. / Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo. In: International Journal of Radiation Applications and Instrumentation. 1989 ; Vol. 16, No. 6.
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