Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions

Fabrizia Salerni, Rodolfo Repetto, Alon Harris, Peter Pinsky, Christophe Prud'homme, Marcela Szopos, Giovanna Guidoboni

Research output: Contribution to journalArticle

Abstract

This work aims at investigating the interactions between the flow of fluids in the eyes and the brain and their potential implications in structural and functional changes in the eyes of astronauts, a condition also known as spaceflight associated neuro-ocular syndrome (SANS). To this end, we propose a reduced (0-dimensional) mathematical model of fluid flow in the eyes and brain, which is embedded into a simplified whole-body circulation model. In particular, the model accounts for: (i) the flows of blood and aqueous humor in the eyes; (ii) the flows of blood, cerebrospinal fluid and interstitial fluid in the brain; and (iii) their interactions. The model is used to simulate variations in intraocular pressure, intracranial pressure and blood flow due to microgravity conditions, which are thought to be critical factors in SANS. Specifically, the model predicts that both intracranial and intraocular pressures increase in microgravity, even though their respective trends may be different. In such conditions, ocular blood flow is predicted to decrease in the choroid and ciliary body circulations, whereas retinal circulation is found to be less susceptible to microgravity-induced alterations, owing to a purely mechanical component in perfusion control associated with the venous segments. These findings indicate that the particular anatomical architecture of venous drainage in the retina may be one of the reasons why most of the SANS alterations are not observed in the retina but, rather, in other vascular beds, particularly the choroid. Thus, clinical assessment of ocular venous function may be considered as a determinant SANS factor, for which astronauts could be screened on earth and inflight.

Original languageEnglish (US)
Article numbere0216012
JournalPLoS ONE
Volume14
Issue number8
DOIs
StatePublished - Jan 1 2019

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microgravity
Weightlessness
Microgravity
Brain
Blood
eyes
brain
space flight
Space Flight
Flow of fluids
blood flow
Cerebrospinal fluid
Astronauts
Choroid
Drainage
retina
Intraocular Pressure
Earth (planet)
Retina
Mathematical models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Salerni, F., Repetto, R., Harris, A., Pinsky, P., Prud'homme, C., Szopos, M., & Guidoboni, G. (2019). Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions. PLoS ONE, 14(8), [e0216012]. https://doi.org/10.1371/journal.pone.0216012

Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions. / Salerni, Fabrizia; Repetto, Rodolfo; Harris, Alon; Pinsky, Peter; Prud'homme, Christophe; Szopos, Marcela; Guidoboni, Giovanna.

In: PLoS ONE, Vol. 14, No. 8, e0216012, 01.01.2019.

Research output: Contribution to journalArticle

Salerni, F, Repetto, R, Harris, A, Pinsky, P, Prud'homme, C, Szopos, M & Guidoboni, G 2019, 'Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions', PLoS ONE, vol. 14, no. 8, e0216012. https://doi.org/10.1371/journal.pone.0216012
Salerni, Fabrizia ; Repetto, Rodolfo ; Harris, Alon ; Pinsky, Peter ; Prud'homme, Christophe ; Szopos, Marcela ; Guidoboni, Giovanna. / Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions. In: PLoS ONE. 2019 ; Vol. 14, No. 8.
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