Biological effects of staphylococcal cell wall and its components in mice

R. Dziarski, K. Kwarecki

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Abstract

Staphylococcal cell wall preparations, teichoic acid and peptidoglycan extract from the cell walls were used in the animal experiments. Mice were thymectomized and injected with 1 dose of peptidoglycan i.v. The animals were challenged with sublethal doses of staphylococci given either at the time of peptidoglycan injection or at weekly intervals up to 4 wk after the injection. Virulence and immunologic responses were studied. Animals treated with peptidoglycan were more susceptible to staphylococcal infections than controls even 4 wk after injection. Experiments indicate that a single i.v. injection of peptidoglycan produces delayed hypersensitivity which is a factor enhancing virulence of the staphylococcal challenge. Tissue localization and persistence of peptidoglycan or cell wall preparations in mouse organs were also studied. Peptidoglycan was found in the liver and spleen even after 16 wk and this persistence may contribute to the prolonged effect of a single i.v. injection. (G.W. Csonka - Radlett - U.K.)

Original languageEnglish (US)
Pages (from-to)393-406
Number of pages14
JournalZBL.BAKT.REIHE A
Volume235
Issue numbersup.5
StatePublished - Jan 1 1976

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ASJC Scopus subject areas

  • Medicine(all)

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