Biological effects of staphylococcal cell wall and its components in mice

Roman Dziarski, K. Kwarecki

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Staphylococcal cell wall preparations, teichoic acid and peptidoglycan extract from the cell walls were used in the animal experiments. Mice were thymectomized and injected with 1 dose of peptidoglycan i.v. The animals were challenged with sublethal doses of staphylococci given either at the time of peptidoglycan injection or at weekly intervals up to 4 wk after the injection. Virulence and immunologic responses were studied. Animals treated with peptidoglycan were more susceptible to staphylococcal infections than controls even 4 wk after injection. Experiments indicate that a single i.v. injection of peptidoglycan produces delayed hypersensitivity which is a factor enhancing virulence of the staphylococcal challenge. Tissue localization and persistence of peptidoglycan or cell wall preparations in mouse organs were also studied. Peptidoglycan was found in the liver and spleen even after 16 wk and this persistence may contribute to the prolonged effect of a single i.v. injection. (G.W. Csonka - Radlett - U.K.)

Original languageEnglish (US)
Title of host publicationZBL.BAKT.REIHE A
Pages393-406
Number of pages14
Volume235
Editionsup.5
StatePublished - 1976
Externally publishedYes

Fingerprint

Peptidoglycan
Cell Wall
Injections
Teichoic Acids
Staphylococcal Infections
Delayed Hypersensitivity
Virulence Factors
Infection Control
Staphylococcus
Virulence
Spleen
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dziarski, R., & Kwarecki, K. (1976). Biological effects of staphylococcal cell wall and its components in mice. In ZBL.BAKT.REIHE A (sup.5 ed., Vol. 235, pp. 393-406)

Biological effects of staphylococcal cell wall and its components in mice. / Dziarski, Roman; Kwarecki, K.

ZBL.BAKT.REIHE A. Vol. 235 sup.5. ed. 1976. p. 393-406.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dziarski, R & Kwarecki, K 1976, Biological effects of staphylococcal cell wall and its components in mice. in ZBL.BAKT.REIHE A. sup.5 edn, vol. 235, pp. 393-406.
Dziarski R, Kwarecki K. Biological effects of staphylococcal cell wall and its components in mice. In ZBL.BAKT.REIHE A. sup.5 ed. Vol. 235. 1976. p. 393-406
Dziarski, Roman ; Kwarecki, K. / Biological effects of staphylococcal cell wall and its components in mice. ZBL.BAKT.REIHE A. Vol. 235 sup.5. ed. 1976. pp. 393-406
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